Effects of aging upon the host response to implants.
Effects of aging upon the host response to implants.
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DOI：
10.1002/jbm.a.36013
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Brown BN
中科院分区：
文献类型：
--
作者：
Hachim D;Wang N;Lopresti ST;Stahl EC;Umeda YU;Rege RD;Carey ST;Mani D;Brown BN
现在，宿主反应中的巨噬细胞极化是材料植入后预后的一个公认的预测指标。老年人的免疫衰老、巨噬细胞功能的失调以及免疫反应的延迟分解都已被证明，这表明老年人对物质的宿主反应应该与年轻个体不同。然而，很少有研究研究老化对宿主反应的影响。本研究旨在阐明老化对8周龄和18月龄小鼠植入聚丙烯网状物后宿主反应的影响。结果表明，18月龄小鼠和8月龄小鼠在宿主巨噬细胞早期反应和宿主反应延迟分解过程中，巨噬细胞表面标志物的表达、迁移和极化存在显著差异。这些差异不能仅仅归因于细胞固有的缺陷，这表明宿主巨噬细胞对植入物的反应可能在很大程度上也取决于局部组织微环境。这些结果对通常用于治疗老年人的材料和设备的设计和测试提出了重要的问题，并表明对患者和上下文相关的巨噬细胞反应的更好理解有可能改善老年人的预后。
Macrophage polarization during the host response is now a well-accepted predictor of outcomes following material implantation. Immunosenescence, dysregulation of macrophage function, and delayed resolution of immune responses in aged individuals have all been demonstrated, suggesting that host responses to materials in aged individuals should differ from those in younger individuals. However, few studies examining the effects of aging upon the host response have been performed. The present work sought to elucidate the impacts of aging upon the host response to polypropylene mesh implanted into 8-week-old and 18-month-old mice. The results showed that there are significant differences in macrophage surface marker expression, migration, and polarization during the early host macrophage response and delayed resolution of the host response in 18-month-old versus 8-week-old mice. These differences could not be attributed to cell-intrinsic defects alone, suggesting that the host macrophage response to implants is likely also dictated to a significant degree by the local tissue microenvironment. These results raise important questions about the design and testing of materials and devices often intended to treat aged individuals and suggest that an improved understanding of patient- and context-dependent macrophage responses has the potential to improve outcomes in aged individuals.
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影响因子：
2
作者：
Campos, Paula P.;Vasconcelos, Anilton C.;Andrade, Silvia P.
通讯作者：
Andrade, Silvia P.
影响因子：
4.4
作者：
den Dekker, Els;Grefte, Sander;Torensma, Ruurd
通讯作者：
Torensma, Ruurd
影响因子：
14
作者：
Guo R;Merkel AR;Sterling JA;Davidson JM;Guelcher SA
通讯作者：
Guelcher SA
DOI：
10.1093/jnci/51.4.1275
发表时间：
1973-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
KARP, RD;JOHNSON, KH;BRAND, KG
通讯作者：
BRAND, KG
与CD47功能化血接触表面的血小板和中性粒细胞的粘附和激活减少。
影响因子：
14
作者：
Finley, Matthew J.;Rauova, Lubica;Alferiev, Ivan S.;Weisel, John W.;Levy, Robert J.;Stachelek, Stanley J.
通讯作者：
Stachelek, Stanley J.