Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role.
Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role.
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DOI：
10.3389/fncel.2013.00074
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发表时间：
2013
影响因子：
5.3
通讯作者：
Goto S
中科院分区：
文献类型：
--
作者：
Koizumi H;Morigaki R;Okita S;Nagahiro S;Kaji R;Nakagawa M;Goto S
阿片肽受体由三个主要亚类组成，即μ、δ和κ（分别为莫尔、DOR和KOR）。它们参与调节纹状体多巴胺功能，阿片类药物传输的增加被认为在帕金森病（PD）基底神经节功能改变中发挥着补偿作用。在这项研究中，我们使用免疫组织化学与酪胺信号放大（TSA）协议，以确定阿片受体的分布模式在纹状体基质系统的大鼠纹状体。作为纹状体阿片解剖学的最显著特征，MORs高度富集于纹状体和胼胝体下条。我们还发现，DORs定位在背侧纹状体（尾状核-壳核）的马赛克图案，与相对于基质隔室的纹状体中的DOR标记升高。在6-羟基多巴胺损伤的PD大鼠模型中，黑质纹状体通路的损伤导致纹状体标记的纹状体中的莫尔和DOR的显著减少，但在基质隔室中没有。我们的研究结果表明，纹状体和基质区室的活性受到涉及MORs和DORs的阿片信号的差异调节，并且纹状体可能对阿片肽（例如，脑啡肽）比基质隔室。基于一个模型，其中的纹状体区室调节纹状体的活动，我们提出了一个强有力的补偿作用，纹状体阿片样物质信号的条件下，发生在PD的纹状体多巴胺耗竭。
The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's disease (PD). In this study, we used an immunohistochemistry with tyramide signal amplification (TSA) protocols to determine the distributional patterns of opioid receptors in the striosome-matrix systems of the rat striatum. As a most striking feature of striatal opioid anatomy, MORs are highly enriched in the striosomes and subcallosal streak. We also found that DORs are localized in a mosaic pattern in the dorsal striatum (caudate-putamen), with heightened labeling for DOR in the striosomes relative to the matrix compartment. In the 6-hydroxydopamine-lesioned rat model of PD, lesions of the nigrostriatal pathways caused a significant reduction of striatal labeling for both the MOR and DOR in the striosomes, but not in the matrix compartment. Our results suggest that the activities of the striosome and matrix compartments are differentially regulated by the opioid signals involving the MORs and DORs, and that the striosomes may be more responsive to opioid peptides (e.g., enkephalin) than the matrix compartment. Based on a model in which the striosome compartment regulates the striatal activity, we propose a potent compensatory role of striosomal opioid signaling under the conditions of the striatal dopamine depletion that occurs in PD.
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影响因子：
5.3
作者：
Blomeley, Craig P.;Bracci, Enrico
通讯作者：
Bracci, Enrico
影响因子：
2.9
作者：
Crittenden JR;Graybiel AM
通讯作者：
Graybiel AM
影响因子：
16.2
作者：
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide
影响因子：
2.5
作者：
Cahill, CM;McClellan, KA;Beaudet, A
通讯作者：
Beaudet, A
DOI：
10.1073/pnas.0812822106
发表时间：
2009-02-24
影响因子：
11.1
作者：
Crittenden, Jill R.;Cantuti-Castelvetri, Ippolita;Graybiel, Ann M.
通讯作者：
Graybiel, Ann M.