Factors relevant to atrial (18)F-fluorodeoxyglucose uptake in atrial fibrillation.
Factors relevant to atrial (18)F-fluorodeoxyglucose uptake in atrial fibrillation.
复制标题
房颤时心房 18F-氟脱氧葡萄糖摄取的相关因素
DOI：
10.1007/s12350-018-1387-4
复制
发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Yang MF
中科院分区：
文献类型：
--
作者：
Xie B;Chen BX;Wu JY;Liu X;Yang MF
背景：本回顾性研究旨在探讨房颤（AF）患者接受常规全身正电子发射断层扫描/计算机断层扫描（PET/CT）imaging. Methods和results：48例连续AF患者（32例持续性，16例阵发性）的相关因素。选择22例正常对照者，确定靶组织FDG摄取（最大标准摄取值，SUVmax）的正常范围。计算靶背景比（TBR）以确定心房和心耳（AA）中的异常摄取。通过单因素比较和多因素回归分析，探讨FDG在心房和AA中蓄积增加的相关因素。17例房颤患者（均为持续性房颤）心房FDG摄取增加。其中大多数（14例，即82.4%）右心房摄取增加。11例AF患者（9例持续性AF）AA摄取增加，双侧AA同样受累。多变量logistic回归分析发现，女性、持续性AF和心外膜脂肪组织（EAT）活动是预测心房活动增加的独立因素;此外，发现左心室SUV max与AA有关。此外，多元线性回归分析表明，EAT活动是唯一的独立变量与心房和AA的活动线性相关。结论：心房摄取存在于持续性AF和本地化主要在右心房，而双边AA可能同样参与。心房肌电活动增加的原因是多方面的，尤其是EAT活动与心房肌电活动和AA独立相关。
Background:This retrospective study was designed to explore the factors relevant to increased atrial18F-fluorodeoxyglucose (FDG) uptake in patients with atrial fibrillation (AF) who had undergone routine whole-body positron emission tomography/computed tomography (PET/CT) imaging.Methods and results:Forty-eight consecutive AF patients (32 persistent, 16 paroxysmal) were identified from our routine FDG PET/CT database. Twenty-two control subjects were selected to establish the normal range of FDG uptake (maximum standardized uptake value, SUVmax) in target tissues. A target-to-background ratio (TBR) was calculated to determine abnormal uptake in the atrium and atrial appendage (AA). Univariate comparisons and multivariate regression analyses were conducted to explore the factors associated with the increased FDG accumulation in the atrium and AA. Seventeen AF patients, all with persistent AF, had increased atrial FDG uptake. Most of them (14, or 82.4%) had increased uptake in the right atrium. Eleven AF patients, 9 with persistent AF, had increased uptake in the AA, and bilateral AAs were equally involved. Multivariate logistic regression analyses identified that female gender, persistent AF, and activity in epicardial adipose tissue (EAT) were independent factors predicting the increased activity of the atrium; also, SUVmaxof the left ventricle was found for the AA. In addition, multivariate linear regression analyses showed that EAT activity was the only independent variable linearly correlated with the activity of the atrium and AA.Conclusions:Atrial uptake was present in persistent AF and localized mainly in the right atrium, whereas bilateral AAs could be equally involved. Multiple factors contributed to the increased activity in atrium; in particular, the EAT activity was independently correlated with the activity of the atrium and AA.
登录
查看更多内容
DOI：
10.1007/s12350-016-0502-7
发表时间：
2017-03
期刊：
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
影响因子：
--
作者：
Osborne MT;Hulten EA;Murthy VL;Skali H;Taqueti VR;Dorbala S;DiCarli MF;Blankstein R
通讯作者：
Blankstein R
DOI：
10.1007/s12350-015-0226-0
发表时间：
2016-04
期刊：
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
影响因子：
--
作者：
Manabe O;Yoshinaga K;Ohira H;Masuda A;Sato T;Tsujino I;Yamada A;Oyama-Manabe N;Hirata K;Nishimura M;Tamaki N
通讯作者：
Tamaki N
DOI：
10.1007/s10554-015-0766-z
发表时间：
2016-01
期刊：
The international journal of cardiovascular imaging
影响因子：
--
作者：
Joseph P;Ishai A;MacNabb M;Abdelbaky A;Lavender ZR;Ruskin J;Nahrendorf M;Tawakol A
通讯作者：
Tawakol A
DOI：
10.1161/circimaging.113.001093
发表时间：
2014-05-01
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Kim, Eung Ju;Kim, Sungeun;Seo, Hong Seog
通讯作者：
Seo, Hong Seog
影响因子：
37.8
作者：
Mazurek, T;Zhang, LF;Shi, Y
通讯作者：
Shi, Y