Phase Separation in Germ Cells and Development.

Phase Separation in Germ Cells and Development.
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DOI:
10.1016/j.devcel.2020.09.004
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发表时间:
2020-10-12
期刊:
影响因子:
11.8
通讯作者:
Kennedy S
Kennedy S
中科院分区:
生物学1区
文献类型:
--
作者:
Dodson AE;Kennedy S

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动物生殖系是一种永生细胞谱系,每一代产生卵子和/或精子。卵子和精子的融合,或受精,引发了一系列的发育事件,能够产生一系列不同的细胞类型和身体计划。生殖细胞如何发育、发挥功能并最终产生全新的生物体是生物学中的一个重要问题。越来越多的证据表明,相分离事件可能在生殖细胞和发育中发挥重要和多方面的作用。在这里,我们讨论生殖细胞中相分离区室的组织、动力学和潜在功能,并研究相分离可能有助于多细胞生物发育的各种方式。
The animal germline is an immortal cell lineage that gives rise to eggs and/or sperm each generation. Fusion of an egg and sperm, or fertilization, sets off a cascade of developmental events capable of producing an array of different cell types and body plans. How germ cells develop, function, and eventually give rise to entirely new organisms is an important question in biology. A growing body of evidence suggests that phase separation events likely play a significant and multifaceted role in germ cells and development. Here, we discuss the organization, dynamics, and potential functions of phase-separated compartments in germ cells and examine the various ways in which phase separation might contribute to the development of multicellular organisms.
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