Molecular mechanisms of mechanosensing and their roles in fungal contact sensing.

Molecular mechanisms of mechanosensing and their roles in fungal contact sensing.
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机械感应的分子机制及其在真菌接触传感中的作用。

DOI:
10.1038/nrmicro1960
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发表时间:
2008-09
期刊:
Nature reviews. Microbiology
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其他
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许多真菌物种通过分化来响应与表面的接触。植物病原真菌与表面的接触导致复杂结构的精细化,使其能够入侵寄主植物,而对于条件人类病原体白色念珠菌,与半固体表面的接触导致入侵生长到下层材料。因此,感知与适当表面接触的能力有助于这些真菌在各自的宿主中致病。本文讨论了机械敏感的分子机制,涉及的蛋白质,如机械敏感离子通道、G蛋白偶联受体和整合素,以及它们在真菌接触传感中的可能作用。
Numerous fungal species respond to contact with a surface by undergoing differentiation. Contact between plant pathogenic fungi and a surface results in the elaboration of the complex structures that enable invasion of the host plant, and for the opportunistic human pathogen Candida albicans, contact with a semi-solid surface results in invasive growth into the subjacent material. The ability to sense contact with an appropriate surface therefore contributes to the ability of these fungi to cause disease in their respective hosts. This Review discusses molecular mechanisms of mechanosensitivity, the proteins involved, such as mechanosensitive ion channels, G-protein-coupled receptors and integrins, and their putative roles in fungal contact sensing.
白色念珠菌的菌丝取向受钙依赖性机制调节。
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