Sleep changes without medial temporal lobe or brain cortical changes in community-dwelling individuals with subjective cognitive decline.
Sleep changes without medial temporal lobe or brain cortical changes in community-dwelling individuals with subjective cognitive decline.
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DOI：
10.1016/j.jalz.2016.11.006
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Tartaro A
中科院分区：
文献类型：
--
作者：
Lauriola M;Esposito R;Delli Pizzi S;de Zambotti M;Londrillo F;Kramer JH;Rabinovici GD;Tartaro A
主观认知功能减退（SCD）是轻度认知功能障碍（MCI）和阿尔茨海默病（AD）的危险因素。虽然MCI和AD患者的睡眠被证明会改变，但对SCD患者的睡眠知之甚少。70名认知正常的社区居民参与者使用主观认知下降问卷被分类为SCD（32）或对照组（38）。使用活动记录仪和日记评估睡眠。FreeSurfer用于执行3 T磁共振图像的内侧颞叶（MTL）和大脑皮质分割。使用多元回归模型评估组间睡眠、MTL或区域皮质差异的存在。SCD参与者的客观睡眠被破坏，这表明夜间觉醒增加，睡眠效率降低。主观睡眠或磁共振成像结果没有组间差异。客观睡眠中断社区居住的SCD，没有任何主观睡眠或皮质的变化。睡眠评估/干预SCD可能有助于预防/延迟AD发作。
Subjective cognitive decline (SCD) is a risk factor for mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Although sleep has been shown to be altered in MCI and AD, little is known about sleep in SCD. Seventy cognitively normal community-dwelling participants were classified as SCD (32) or controls (38) using the Subjective Cognitive Decline Questionnaire. Sleep was assessed using actigraphy and diaries. FreeSurfer was used for performing medial temporal lobes (MTLs) and brain cortical parcellation of 3T magnetic resonance images. Multiple regression models were used to assess the presence of sleep, MTL, or regional cortical differences between groups. Objective sleep was disrupted in SCD participants, which showed increased nighttime wakefulness and reduced sleep efficiency. No group differences emerged in subjective sleep or magnetic resonance imaging outcomes. Objective sleep resulted disrupted in community-dwelling SCD, without any subjective sleep or cortical change. Sleep assessment/intervention in SCD might help prevent/delay AD onset.
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影响因子：
38.1
作者：
Frisoni, Giovanni B.;Fox, Nick C.;Jack, Clifford R., Jr.;Scheltens, Philip;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
5.6
作者：
Joo, Eun Yeon;Kim, Hosung;Hong, Seung Bong
通讯作者：
Hong, Seung Bong
影响因子：
4.3
作者：
Berry, Richard B.;Budhiraja, Rohit;Tangredi, Michelle M.
通讯作者：
Tangredi, Michelle M.
影响因子：
4.2
作者：
Convit, A;DeLeon, MJ;George, A
通讯作者：
George, A
DOI：
10.1016/j.jalz.2014.01.001
发表时间：
2014-11
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jessen F;Amariglio RE;van Boxtel M;Breteler M;Ceccaldi M;Chételat G;Dubois B;Dufouil C;Ellis KA;van der Flier WM;Glodzik L;van Harten AC;de Leon MJ;McHugh P;Mielke MM;Molinuevo JL;Mosconi L;Osorio RS;Perrotin A;Petersen RC;Rabin LA;Rami L;Reisberg B;Rentz DM;Sachdev PS;de la Sayette V;Saykin AJ;Scheltens P;Shulman MB;Slavin MJ;Sperling RA;Stewart R;Uspenskaya O;Vellas B;Visser PJ;Wagner M;Subjective Cognitive Decline Initiative (SCD-I) Working Group
通讯作者：
Subjective Cognitive Decline Initiative (SCD-I) Working Group