Finite element analysis of osteoporosis models based on synchrotron radiation
Finite element analysis of osteoporosis models based on synchrotron radiation
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基于同步辐射的骨质疏松模型有限元分析
DOI：
10.1088/1748-0221/11/04/c04002
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发表时间：
2016-04
影响因子：
1.3
通讯作者：
Jianqi Sun
中科院分区：
文献类型：
--
作者：
Wangyang Xu;Jun Xu;Jun Zhao;Jianqi Sun
随着社会老龄化压力日益加大，中国乃至全球骨质疏松症患者数量不断增加。近年来，同步辐射以其高分辨率和高稳定性的优势已成为生物医学探索的重要工具。为了研究原发性骨质疏松症不同阶段的特征性变化，本研究基于同步辐射对大鼠骨质疏松症的不同时期进行了研究。然后根据重建的三维模型进行骨组织形态测量分析和有限元分析。最后定量比较不同时期骨组织的变化。组织形态计量学分析表明，骨质疏松症的小梁结构随着骨量的减少而退化。对于股骨，骨体积分数（骨体积/总体积，BV/TV）从 69% 下降至 43%。这导致小梁分离厚度增加（从45.05μm到97.09μm）和小梁数量减少（从7.99mm-1到5.97mm-1）。通过有限元分析（FEA）模拟各种力学测试表明，随着骨质疏松症的加剧，骨骼抵抗压缩、弯曲和扭转的能力逐渐变弱。股骨的压缩刚度从1770.96 Fμ m−1下降到697.41 Fμ m−1，弯曲和扭转刚度分别从1390.80 Fμ m−1下降到566.11 Fμ m−1，从2957.28N.m/̂下降到691.31 N.m/̂，表明骨强度下降，与组织形态计量学分析。这项研究表明，有限元分析和同步加速器辐射是结合组织形态计量分析分析骨强度的绝佳方法。
With growing pressure of social aging, China has to face the increasing population of osteoporosis patients as well as the whole world. Recently synchrotron radiation has become an essential tool for biomedical exploration with advantage of high resolution and high stability. In order to study characteristic changes in different stages of primary osteoporosis, this research focused on the different periods of osteoporosis of rats based on synchrotron radiation. Both bone histomorphometry analysis and finite element analysis were then carried on according to the reconstructed three dimensional models. Finally, the changes of bone tissue in different periods were compared quantitatively. Histomorphometry analysis showed that the structure of the trabecular in osteoporosis degraded as the bone volume decreased. For femurs, the bone volume fraction (Bone volume/ Total volume, BV/TV) decreased from 69% to 43%. That led to the increase of the thickness of trabecular separation (from 45.05μ m to 97.09μ m) and the reduction of the number of trabecular (from 7.99 mm-1 to 5.97mm-1). Simulation of various mechanical tests with finite element analysis (FEA) indicated that, with the exacerbation of osteoporosis, the bones' ability of resistance to compression, bending and torsion gradually became weaker. The compression stiffness of femurs decreased from 1770.96 Fμ m−1 to 697.41 Fμ m−1, the bending and torsion stiffness were from 1390.80 Fμ m−1 to 566.11 Fμ m−1 and from 2957.28N.m/̂ to 691.31 N.m/̂ respectively, indicated the decrease of bone strength, and it matched the histomorphometry analysis. This study suggested that FEA and synchrotron radiation were excellent methods for analysing bone strength conbined with histomorphometry analysis.
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影响因子：
0.7
作者：
J. Pelka
通讯作者：
J. Pelka
DOI：
--
发表时间：
1979
期刊：
--
影响因子：
--
作者：
C. Kunz;K. Codling
通讯作者：
C. Kunz;K. Codling
DOI：
--
发表时间：
2006
期刊：
High Power Laser and Particle Beams
影响因子：
--
作者：
Yun Cheng-hao
通讯作者：
Yun Cheng-hao
影响因子：
1.6
作者：
肖体乔 Xiao Tiqiao;谢红兰 Xie Honglan;邓. D. Biao;杜国浩 Du Guohao;陈荣昌 Chen Rongchang
通讯作者：
肖体乔 Xiao Tiqiao;谢红兰 Xie Honglan;邓. D. Biao;杜国浩 Du Guohao;陈荣昌 Chen Rongchang
影响因子：
2.2
作者：
Lazo, MG;Shirazi, P;Muppidi, M
通讯作者：
Muppidi, M