Pretreatment TACC3 expression in locally advanced rectal cancer decreases the response to neoadjuvant chemoradiotherapy.
Pretreatment TACC3 expression in locally advanced rectal cancer decreases the response to neoadjuvant chemoradiotherapy.
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局部晚期直肠癌治疗前 TACC3 表达降低对新辅助放化疗的反应
DOI：
10.18632/aging.101585
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发表时间：
2018-10-19
期刊：
影响因子：
--
通讯作者：
Zhang RX
中科院分区：
文献类型：
--
作者：
Ma WJ;Gu YK;Peng JH;Wang XC;Yue X;Pan ZZ;Chen G;Xu HN;Zhou ZG;Zhang RX
放化疗联合手术切除是局部晚期直肠癌的标准治疗方法，但并非所有患者对新辅助治疗都有反应。转化酸性卷曲螺旋蛋白-3（TACC 3）在直肠癌组织中经常异常表达。在这项研究中，我们研究了TACC 3是否可以作为预测放化疗疗效的生物标志物。总共有152例直肠癌患者在活检时收集了肿瘤组织，并在治疗前将其放在一边。所有患者均接受放化疗和手术切除。免疫组化检测的肿瘤TACC 3表达显著降低了对放化疗的敏感性[风险比（RR）= 2.236，95%可信区间（CI）：1.447-3.456; P = 0.001]，从而降低了病理学完全缓解率（P = 0.001）。使用特异性siRNA敲除TACC 3增强了放疗诱导的HCT 116和SW 480细胞增殖和集落形成的减少，并增加了放疗诱导的凋亡的发生率。考克斯多因素分析显示TACC 3是总生存期（P = 0.017）和无病生存期（P = 0.020）的显著预后因素。这些结果表明，TACC 3表达可能是局部进展期直肠癌放化疗敏感性和预后的预测。
Chemoradiotherapy combined with surgical resection is the standard treatment for locally advanced rectal cancer, but not all the patients respond to neoadjuvant treatment. Transforming acidic coiled-coil protein-3 (TACC3) is frequently aberrantly expressed in rectal cancer tissue. In this study, we investigated whether TACC3 could serve as a biomarker predictive of the efficacy of chemoradiotherapy. In all, 152 rectal cancer patients with tumor tissue collected at biopsy and set aside before treatment were enrolled in this study. All patients received chemoradiotherapy and surgical resection. Immunohistochemically detected tumoral TACC3 expression significantly decreased sensitivity to chemoradiotherapy [risk ratio (RR) = 2.236, 95% confidence interval (CI): 1.447–3.456; P = 0.001] and thus the pathological complete response rate (P = 0.001). TACC3 knockdown using specific siRNA enhanced radiotherapy-induced decreases in proliferation and colony formation by HCT116 and SW480 cells and increased the incidence of radiotherapy-induced apoptosis. Cox multivariate analysis showed that TACC3 was a significant prognostic factor for overall survival (P = 0.017) and disease-free survival (P = 0.020). These findings suggest TACC3 expression may be predictive of chemoradiotherapy sensitivity and prognosis in locally advanced rectal cancer.
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影响因子：
10.5
作者：
Gergely, F;Draviam, VM;Raff, JW
通讯作者：
Raff, JW
影响因子：
--
作者：
Duncan CG;Killela PJ;Payne CA;Lampson B;Chen WC;Liu J;Solomon D;Waldman T;Towers AJ;Gregory SG;McDonald KL;McLendon RE;Bigner DD;Yan H
通讯作者：
Yan H
TACC3 促进结直肠癌肿瘤发生并与不良预后相关
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作者：
Du Y;Liu L;Wang C;Kuang B;Yan S;Zhou A;Wen C;Chen J;Wu Y;Yang X;Feng G;Liu B;Iwamoto A;Zeng M;Wang J;Zhang X;Liu H
通讯作者：
Liu H
TACC3在食管鳞状细胞癌中的高表达与不良预后相关
影响因子：
--
作者：
Huang ZL;Lin ZR;Xiao YR;Cao X;Zhu LC;Zeng MS;Zhong Q;Wen ZS
通讯作者：
Wen ZS
影响因子：
45.3
作者：
Gerard, Jean-Pierre;Azria, David;Conroy, Thierry
通讯作者：
Conroy, Thierry