Functional and Structural Diversity of Acyl-coA Binding Proteins in Oil Crops.
Functional and Structural Diversity of Acyl-coA Binding Proteins in Oil Crops.
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油料作物中酰基辅酶A结合蛋白的功能和结构多样性
DOI：
10.3389/fgene.2018.00182
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发表时间：
2018
影响因子：
3.7
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Raboanatahiry N;Wang B;Yu L;Li M
本文就ACBP在结构和功能上的多样性作一综述。ACBP是一种重要的蛋白质，可以将新合成的脂肪酸从质体运输到内质网，并活化成-coA，在内质网中以三酰基甘油的形式产生油。在多种动物和植物中均检测到ACBP，表明其具有重要的生物学功能。事实上，一些研究已经证实ACBP参与脂质代谢、酶和基因表达调控以及植物对胁迫的响应等重要过程。本文综述了11种知名油料作物ACBP的研究成果，对其结构进行了比较分析，并对ACBP的结构与功能、组织表达和亚细胞定位进行了探讨。一些物种的不完整报告被提及，这可能会鼓励开始或进行更深入的研究。同源ACBP具有相似的特征，而同源ACBP具有不同的功能，尽管它们在氨基酸序列上具有较高的一致性。最后，证实了同源蛋白不一定表现出相同的功能，即使是来自密切相关的物种。
Diversities in structure and function of ACBP were discussed in this review. ACBP are important proteins that could transport newly synthesized fatty acid, activated into -coA, from plastid to endoplasmic reticulum, where oil in the form of triacylglycerol occurs. ACBP were detected in various animal and plants species, which indicated their importance in biological function. In fact, involvement of ACBP in important process such as lipid metabolism, regulation of enzyme and gene expression, and in response to plant stresses has been proven in several studies. In this review, findings on ACBP of 11 well-known oil crops were reviewed to comprehend diversity, comparative analyses on ACBP structure were made, and link between structure and function, tissue expression and subcellular location of ACBP were also observed. Incomplete reports in some species were mentioned, which might be encouraging to start or to perform deeper studies. Similar characteristics were found in paralogs ACBP, and orthologs ACBP had different functions, despite the high identity in amino acid sequence. At the end, it is confirmed that ortholog proteins could not necessarily display the same function, even from closely related species.
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