Cholecystokinin octapeptide induces endogenous opioid-dependent anxiolytic effects in morphine-withdrawal rats
Cholecystokinin octapeptide induces endogenous opioid-dependent anxiolytic effects in morphine-withdrawal rats
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胆囊收缩素八肽在吗啡戒断大鼠中诱导内源性阿片依赖性抗焦虑作用
DOI：
10.1016/j.neuroscience.2014.06.048
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发表时间：
2014-09
期刊：
影响因子：
3.3
通讯作者：
Cong, B.
中科院分区：
文献类型：
--
作者：
Liu, X.;Yu, F.;Ma, C.;Cong, B.
Cholecystokinin octapeptide (CCK-8), a brain–gut peptide, plays an important role in several opioid addictive behaviors. We previously reported that CCK-8 attenuated the expression and reinstatement of morphine-induced conditioned place preference. The possible effects of CCK-8 on the negative affective components of drug abstinence are not clear. There are no studies evaluating the effect of CCK-8 on emotional symptoms, such as anxiety, in morphine-withdrawal animals. We investigated the effects of CCK-8 on the anxiety-like behavior in morphine-withdrawal rats using an elevated plus-maze. Morphine withdrawal elicited time-dependent anxiety-like behaviors with peak effects on day 10 (5 days after induction of morphine dependence). Treatment with CCK-8 (0.1 and 1 μg, i.c.v.) blocked this anxiety in a dose-dependent fashion. A CCK1 receptor antagonist (L-364,718, 10 μg, i.c.v.) blocked the effect of CCK-8. Mu-opioid receptor antagonism with CTAP (10 μg, i.c.v.) decreased the ‘anxiolytic’ effect. CCK-8 inhibited anxiety-like behaviors in morphine-withdrawal rats by up-regulating endogenous opioidsviathe CCK1 receptor in rats. This study clearly identifies a distinct function of CCK-8 and a potential medication target of central CCK1 receptors for drugs aimed at ameliorating drug addiction.
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CCK-8对吗啡诱导的大鼠CPP恢复及行为敏化表达的影响
影响因子：
3.3
作者：
Wen Di;Zang Guoqing;Sun Donglei;Yang Shengcheng;Yu Feng;Li Shujing;Ma Chunling;Cong Bin
通讯作者：
Cong Bin
影响因子：
2.9
作者：
S. Kõks;A. Soosaar;V. Võikar;V. Volke;M. Ustav;P. Männistö;M. Bourin;E. Vasar
通讯作者：
S. Kõks;A. Soosaar;V. Võikar;V. Volke;M. Ustav;P. Männistö;M. Bourin;E. Vasar
影响因子：
3.6
作者：
Zhongqi Zhang;G. Schulteis
通讯作者：
Zhongqi Zhang;G. Schulteis
影响因子：
2.9
作者：
T. Moran;P. Robinson;M. Goldrich;P. McHugh
通讯作者：
T. Moran;P. Robinson;M. Goldrich;P. McHugh
影响因子：
5
作者：
Rezayof, Ameneh;Nazari-Serenjeh, Farzaneh;Delphi, Ladan
通讯作者：
Delphi, Ladan