Psychological risk factors and the metabolic syndrome in patients with coronary heart disease: findings from the Heart and Soul Study.
Psychological risk factors and the metabolic syndrome in patients with coronary heart disease: findings from the Heart and Soul Study.
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DOI：
10.1016/j.psychres.2009.02.004
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发表时间：
2010-01-30
影响因子：
11.3
通讯作者：
Whooley, Mary A.
中科院分区：
文献类型：
--
作者：
Cohen, Beth E.;Panguluri, Praveen;Na, Beeya;Whooley, Mary A.
心理因素，如抑郁和焦虑，与糖尿病和心血管疾病的风险增加独立相关，但这些关联的原因尚不清楚。我们试图确定心理因素是否与冠心病患者代谢综合征的更高患病率相关，以及这种关联在多大程度上可以通过社会经济地位、健康行为和生物介质来解释。我们对1024例稳定型冠心病门诊患者进行了横断面研究。心理因素，包括抑郁和焦虑症状、敌意、愤怒和乐观-悲观，使用有效的标准化问卷进行评估。代谢综合征的存在与否是根据国家胆固醇教育计划成人治疗小组III概述的标准来确定的。较高水平的抑郁、愤怒、敌意和悲观情绪与代谢综合征患病率的增加显著相关。这些关联可以用社会经济地位和健康行为的差异来解释。对潜在生物介质的额外调整影响不大。需要进一步的研究来确定解决抑郁症患者或高度愤怒或敌意患者的社会经济和行为因素是否可以减轻代谢综合征的负担。
Psychological factors, such as depression and anxiety, are independently associated with an increased risk of both diabetes mellitus and cardiovascular disease, but the reasons for these associations are unknown. We sought to determine whether psychological factors were associated with a greater prevalence of the metabolic syndrome in patients with coronary heart disease, and the extent to which such an association may be explained by socioeconomic status, health behaviors, and biological mediators. We conducted a cross-sectional study of 1024 outpatients with stable coronary heart disease. Psychological factors, including depressive and anxiety symptoms, hostility, anger, and optimism–pessimism, were assessed using validated standardized questionnaires. The presence or absence of the metabolic syndrome was determined using the criteria outlined by the National Cholesterol Education Program, Adult Treatment Panel III. Higher levels of depression, anger expression, hostility, and pessimism were significantly associated with increased prevalence of the metabolic syndrome. These associations were explained by differences in socioeconomic status and health behaviors. Additional adjustment for potential biological mediators had little impact. Further research is needed to determine whether addressing socioeconomic and behavioral factors in people with depression or high levels of anger or hostility could reduce the burden of the metabolic syndrome.
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影响因子：
16.2
作者：
Isomaa, B;Almgren, P;Groop, L
通讯作者：
Groop, L
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