Biomarkers in exhaled breath condensate: a review of collection, processing and analysis.
Biomarkers in exhaled breath condensate: a review of collection, processing and analysis.
复制标题
DOI：
10.1088/1752-7155/2/3/037004
复制
发表时间：
2008-09
影响因子：
3.8
通讯作者：
Dweik RA
中科院分区：
文献类型：
--
作者：
Grob NM;Aytekin M;Dweik RA
呼出气冷凝液（EBC）是无数生物标志物的潜在丰富来源，可以提供有关呼吸系统和全身疾病的有价值信息。EBC已经在多种疾病中进行了研究，包括过敏性鼻炎、哮喘、慢性阻塞性肺病、囊性纤维化、肺癌和阻塞性睡眠呼吸暂停综合征。虽然在EBC中已经发现和研究了许多生物标志物，但收集和生物标志物检测的方法尚未完全标准化。虽然目前将标准化方法留给各个实验室是继续发现EBC中新生物标志物的最佳选择，但这降低了研究结果的可重复性和普遍性。在这篇综述中，我们将讨论在特定疾病中研究的特定生物标志物以及一些相关的技术问题，包括收集，处理和分析。
Exhaled breath condensate (EBC) is a potential rich source for countless biomarkers that can provide valuable information about respiratory as well as systemic diseases. EBC has been studied in a variety of diseases including allergic rhinitis, asthma, chronic obstructive lung disease, cystic fibrosis, lung cancer, and obstructive sleep apnea syndrome. Although numerous biomarkers have been discovered and studied in EBC, the methods of collection and biomarker detection have not been fully standardized. While leaving standardization methods up to individual labs for the present time is optimal for the continued discovery of new biomarkers in EBC, this decreases the reproducibility and generalizability of the findings. In this review we will discuss specific biomarkers studied in specific diseases as well as some of the related technical issues including collection, processing and analysis.
登录
查看更多内容
影响因子：
24.3
作者：
Bayley, D. L.;Abulsiriwil, H.;Stockley, R. A.
通讯作者：
Stockley, R. A.
影响因子：
4.4
作者：
Bodini, A;Peroni, D;Piacentini, GL
通讯作者：
Piacentini, GL
影响因子：
4.6
作者：
Bodini, A.;Peroni, D. G.;Piacentini, G. L.
通讯作者：
Piacentini, G. L.
影响因子：
9.6
作者：
Carpagnano, GE;Barnes, PJ;Kharitonov, SA
通讯作者：
Kharitonov, SA
DOI：
10.1164/rrcm.2061014
发表时间：
2006-04-01
影响因子：
24.7
作者：
通讯作者：
--