Incidence of remission in adults with type 2 diabetes: the diabetes & aging study.
Incidence of remission in adults with type 2 diabetes: the diabetes & aging study.
复制标题
DOI：
10.2337/dc14-0874
复制
发表时间：
2014-12
期刊：
影响因子：
16.2
通讯作者：
Huang ES
中科院分区：
文献类型：
--
作者：
Karter AJ;Nundy S;Parker MM;Moffet HH;Huang ES
评估未经减肥手术治疗的成人2型糖尿病患者的缓解率，并确定与缓解率相关的变量。我们量化了糖尿病缓解的发生率，并在一个综合的医疗保健提供系统中检查了122,781名成年2型糖尿病患者的相关性。缓解需要没有正在进行的药物治疗，其定义如下：1)部分：至少1年亚糖尿病高血糖(HbA1c[HbA1c]水平5.7-6.4%[39-46 mmol/mol])；2)完全：至少1年正常血糖(HbA1c水平和lt；5.7%[-lt；39 mmol/mol])；以及3)延长：完全缓解至少5年。部分缓解、完全缓解和长期缓解的发病率密度(每千人年缓解数；95%CI)分别为2.8(2.6~2.9)、0.24(0.20~0.28)和0.04(0.01~0.06)。7年累计缓解率分别为1.47%(1.40~1.54%)、0.14%(0.12~0.16%)和0.007%(0.003~0.020%)。在整个队列中实现任何缓解的7年累积发生率为1.60%(1.53-1.68%)，在新发糖尿病亚组中(确诊后两年)为4.6%(4.3-4.9%)。在调整人口学和临床特征后，缓解的相关因素包括年龄65岁、非裔美国人、确诊后两年、基线糖化血红蛋白水平5.7%(39 mm o l/m ol)、基线时未服用糖尿病药物。在社区环境中，2型糖尿病的缓解不需要减肥手术，但非常罕见。
To estimate the incidence of remission in adults with type 2 diabetes not treated with bariatric surgery and to identify variables associated with remission. We quantified the incidence of diabetes remission and examined its correlates among 122,781 adults with type 2 diabetes in an integrated healthcare delivery system. Remission required the absence of ongoing drug therapy and was defined as follows: 1) partial: at least 1 year of subdiabetic hyperglycemia (hemoglobin A1c [HbA1c] level 5.7–6.4% [39–46 mmol/mol]); 2) complete: at least 1 year of normoglycemia (HbA1c level <5.7% [<39 mmol/mol]); and 3) prolonged: complete remission for at least 5 years. The incidence density (remissions per 1,000 person-years; 95% CI) of partial, complete, or prolonged remission was 2.8 (2.6–2.9), 0.24 (0.20–0.28), and 0.04 (0.01–0.06), respectively. The 7-year cumulative incidence of partial, complete, or prolonged remission was 1.47% (1.40–1.54%), 0.14% (0.12–0.16%), and 0.007% (0.003–0.020%), respectively. The 7-year cumulative incidence of achieving any remission was 1.60% in the whole cohort (1.53–1.68%) and 4.6% in the subgroup with new-onset diabetes (<2 years since diagnosis) (4.3–4.9%). After adjusting for demographic and clinical characteristics, correlates of remission included age >65 years, African American race, <2 years since diagnosis, baseline HbA1c level <5.7% (<39 mmol/mol), and no diabetes medication at baseline. In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare.
登录
查看更多内容
影响因子：
2.9
作者：
Arterburn DE;Bogart A;Sherwood NE;Sidney S;Coleman KJ;Haneuse S;O'Connor PJ;Theis MK;Campos GM;McCulloch D;Selby J
通讯作者：
Selby J
影响因子：
8.2
作者：
Lim, E. L.;Hollingsworth, K. G.;Aribisala, B. S.;Chen, M. J.;Mathers, J. C.;Taylor, R.
通讯作者：
Taylor, R.
影响因子：
1.9
作者：
Ramos-Levi, Ana M.;Cabrerizo, Lucio;Rubio, Miguel A.
通讯作者：
Rubio, Miguel A.
影响因子：
7.7
作者：
Butler, AE;Janson, J;Butler, PC
通讯作者：
Butler, PC
影响因子：
120.7
作者：
Karter, AJ;Ferrara, A;Selby, JV
通讯作者：
Selby, JV