Fetal Frontolimbic Connectivity Prospectively Associates With Aggression in Toddlers.
Fetal Frontolimbic Connectivity Prospectively Associates With Aggression in Toddlers.
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DOI：
10.1016/j.bpsgos.2022.09.003
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发表时间：
2023-10
期刊：
影响因子：
--
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中科院分区：
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--
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攻击性是一个主要的公共卫生问题，在发展初期就出现了，缺乏优化的治疗，突出了需要改进对攻击病因的机械性理解。目前的研究利用胎儿静息状态功能磁共振成像来确定在症状出现之前攻击行为发生的候选神经回路。孕妇在妊娠晚期被招募来完成胎儿静息状态的功能性磁共振成像扫描。母亲随后完成了儿童行为检查表，以评估产后3年的儿童攻击性(n=79)。独立成分分析用于确定额叶和边缘感兴趣区。儿童攻击性与胎儿皮质下边缘区域的网络连接或前额叶内侧网络的连接无关。然而，即使在控制了母亲情绪调节障碍和幼儿语言能力之后，胎儿皮质下边缘网络和内侧前额叶网络之间较弱的功能耦合也可能与3岁时母亲评定的儿童攻击性更强相关。我们观察到胎儿额缘功能连接和幼儿内化症状之间的相似，但较弱的关联。攻击行为的神经关联可能在子宫中就可以检测到，远远早于攻击症状的出现。这些初步结果强调额缘连接是潜在的候选神经回路，应该进一步研究与儿童行为和精神风险的展开有关的问题。
Aggression is a major public health concern that emerges early in development and lacks optimized treatment, highlighting need for improved mechanistic understanding regarding the etiology of aggression. The present study leveraged fetal resting-state functional magnetic resonance imaging to identify candidate neurocircuitry for the onset of aggressive behaviors before symptom emergence. Pregnant mothers were recruited during the third trimester of pregnancy to complete a fetal resting-state functional magnetic resonance imaging scan. Mothers subsequently completed the Child Behavior Checklist to assess child aggression at 3 years postpartum (n = 79). Independent component analysis was used to define frontal and limbic regions of interest. Child aggression was not related to within-network connectivity of subcortical limbic regions or within–medial prefrontal network connectivity in fetuses. However, weaker functional coupling between the subcortical limbic network and medial prefrontal network in fetuses was prospectively associated with greater maternal-rated child aggression at 3 years of age even after controlling for maternal emotion dysregulation and toddler language ability. We observed similar, but weaker, associations between fetal frontolimbic functional connectivity and toddler internalizing symptoms. Neural correlates of aggressive behavior may be detectable in utero, well before the onset of aggression symptoms. These preliminary results highlight frontolimbic connections as potential candidate neurocircuitry that should be further investigated in relation to the unfolding of child behavior and psychiatric risk.
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影响因子：
2.9
作者：
Cismaru AL;Gui L;Vasung L;Lejeune F;Barisnikov K;Truttmann A;Borradori Tolsa C;Hüppi PS
通讯作者：
Hüppi PS
DOI：
10.1111/jcpp.12364
发表时间：
2015-10
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Gilliam M;Forbes EE;Gianaros PJ;Erickson KI;Brennan LM;Shaw DS
通讯作者：
Shaw DS
DOI：
10.1016/j.jaac.2020.01.024
发表时间：
2021-01-01
影响因子：
13.3
作者：
Gaffrey, Michael S.;Barch, Deanna M.;Petersen, Steven E.
通讯作者：
Petersen, Steven E.
影响因子：
17.7
作者：
Alegria, Analucia A.;Radua, Joaquim;Rubia, Katya
通讯作者：
Rubia, Katya
影响因子：
2.5
作者：
Calhoun, VD;Adali, T;Pekar, JJ
通讯作者：
Pekar, JJ