Maternal depression in childhood and aggression in young adulthood: evidence for mediation by offspring amygdala-hippocampal volume ratio.
Maternal depression in childhood and aggression in young adulthood: evidence for mediation by offspring amygdala-hippocampal volume ratio.
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DOI：
10.1111/jcpp.12364
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Shaw DS
中科院分区：
文献类型：
--
作者：
Gilliam M;Forbes EE;Gianaros PJ;Erickson KI;Brennan LM;Shaw DS
有大量证据表明，抑郁母亲的后代出现与情绪调节相关的持续行为问题的风险增加，但后代出现这种风险的机制尚不完全清楚。早期不良护理经历与杏仁核和海马体的结构改变有关，这与存在与情绪调节相关的行为问题的成年人皮质区域的改变相似。本研究探讨了儿童时期母亲抑郁的暴露是否可能预测成年早期攻击性和/或抑郁的增加，以及后代杏仁核：海马体积比是否可能介导这种关系。参与者是 258 名面临行为问题社会经济风险的母亲和儿子。 Sons 患母亲抑郁症的轨迹是根据前瞻性收集的 18 个月至 10 岁后代的八份报告得出的。在 20 岁时对后代的大脑结构、攻击性和抑郁进行评估 (n=170)。母亲在童年时期持续的、中等偏高的抑郁轨迹预示着成年后代的攻击性会增加。相比之下，童年时期母亲抑郁症的稳定且非常高的轨迹预示着成年后代的抑郁症。 20岁时，杏仁核与海马体体积比的增加与成年后代的攻击性增加显着相关，但与抑郁症无关。后代杏仁核：海马体积比介导了儿童时期母亲抑郁程度中度升高的轨迹与成年后代攻击性之间的关系。与情绪调节有关的大脑结构相对大小的变化可能是抑郁母亲的后代出现攻击性风险增加的机制之一。
There is abundant evidence that offspring of depressed mothers are at increased risk for persistent behavior problems related to emotion regulation, but the mechanisms by which offspring incur this risk are not entirely clear. Early adverse caregiving experiences have been associated with structural alterations in the amygdala and hippocampus, which parallel findings of cortical regions altered in adults with behavior problems related to emotion regulation. The present study examined whether exposure to maternal depression during childhood might predict increased aggression and/or depression in early adulthood, and whether offspring amygdala:hippocampal volume ratio might mediate this relationship. Participants were 258 mothers and sons at socioeconomic risk for behavior problems. Sons’ trajectories of exposure to maternal depression were generated from eight reports collected prospectively from offspring ages 18 months to ten years. Offspring brain structure, aggression, and depression were assessed at age 20 (n=170). Persistent, moderately high trajectories of maternal depression during childhood predicted increased aggression in adult offspring. In contrast, stable and very elevated trajectories of maternal depression during childhood predicted depression in adult offspring. Increased amygdala: hippocampal volume ratios at age 20 were significantly associated with concurrently increased aggression, but not depression, in adult offspring. Offspring amygdala: hippocampal volume ratio mediated the relationship found between trajectories of moderately elevated maternal depression during childhood and aggression in adult offspring. Alterations in the relative size of brain structures implicated in emotion regulation may be one mechanism by which offspring of depressed mothers incur increased risk for the development of aggression.
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影响因子：
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作者：
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