Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction.
Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction.
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DOI：
10.1016/j.neuron.2022.08.022
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发表时间：
2022-11-16
期刊：
影响因子：
16.2
通讯作者：
Watabe-Uchida, Mitsuko
中科院分区：
文献类型：
--
作者：
Akiti, Korleki;Tsutsui-Kimura, Iku;Xie, Yudi;Mathis, Alexander;Markowitz, Jeffrey E.;Anyoha, Rockwell;Datta, Sandeep Robert;Mathis, Mackenzie Weygandt;Uchida, Naoshige;Watabe-Uchida, Mitsuko
动物会探索和避开环境中的新物体，但这些行为及其动态背后的神经机制尚不清楚。在这里，我们使用多点跟踪（DeepLabCut）和行为分割（MoSeq）来表征小鼠与新物体自由互动的行为。新颖性引发了一系列特有的行为，从调查方法开始，最终以对象接触或回避告终。纹状体尾部的多巴胺抑制参与，多巴胺反应可以预测个体行为的可变性。行为动力学和个体可变性可以通过威胁预测的强化学习（RL）模型来解释，在该模型中，行为源于新奇诱导的初始威胁预测（类似于“塑造奖金”），以及通过多巴胺介导的威胁预测错误来学习的威胁预测。这些结果揭示了奖励和威胁相关的多巴胺子系统在算法上的相似性。通过对老鼠行为的自动分析，Akiti等人发现了多种动态的新奇探索模式，包括风险评估、参与和新事物恐惧症。这些行为可以用多巴胺神经元的一个子集来解释，这些神经元将生理上的显著性视为默认的威胁估计，从而导致对新物体的逐步回避。
Animals both explore and avoid novel objects in the environment, but the neural mechanisms that underlie these behaviors and their dynamics remain uncharacterized. Here, we used multi-point tracking (DeepLabCut) and behavioral segmentation (MoSeq) to characterize the behavior of mice freely interacting with a novel object. Novelty elicits a characteristic sequence of behavior, starting with investigatory approach and culminating in object engagement or avoidance. Dopamine in the tail of striatum (TS) suppresses engagement, and dopamine responses were predictive of individual variability in behavior. Behavioral dynamics and individual variability are explained by a reinforcement learning (RL) model of threat prediction, in which behavior arises from a novelty-induced initial threat prediction (akin to “shaping bonus”), and a threat prediction that is learned through dopamine-mediated threat prediction errors. These results uncover an algorithmic similarity between reward- and threat-related dopamine sub-systems. Using automated analysis of mouse behavior, Akiti et al. find diverse and dynamic novelty exploration patterns including risk assessment, engagement, and neophobia. These behaviors can be explained by a subset of dopamine neurons that treat physical salience as a default threat estimate, thereby causing progressive avoidance of the novel object.
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影响因子：
19.9
作者：
Eshel N;Tian J;Uchida N
通讯作者：
Uchida N
神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
1.3
作者：
HOGAN, JA
通讯作者：
HOGAN, JA
影响因子：
5.7
作者：
Jaegle, Andrew;Mehrpour, Vahid;Rust, Nicole
通讯作者：
Rust, Nicole