Disparities in breast cancer: a multi-institutional comparative analysis focusing on American Hispanics.
Disparities in breast cancer: a multi-institutional comparative analysis focusing on American Hispanics.
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DOI：
10.1002/cam4.1509
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发表时间：
2018-06
期刊：
影响因子：
4
通讯作者：
Dwivedi AK
中科院分区：
文献类型：
--
作者：
Nahleh Z;Otoukesh S;Mirshahidi HR;Nguyen AL;Nagaraj G;Botrus G;Badri N;Diab N;Alvarado A;Sanchez LA;Dwivedi AK
乳腺癌（BC）是全国西班牙裔/拉丁裔妇女癌症死亡的主要原因。西班牙裔妇女更有可能出现晚期疾病和不良预后亚型。本研究的目的是描述两个三级护理大学医学中心该组乳腺癌的临床病理特征和差异。获得IRB批准后，癌症登记处用于分析2005年至2015年间在德克萨斯州埃尔帕索和加利福尼亚州洛马琳达的两所大型高等院校医疗和癌症中心数据库中心连续诊断和治疗的3441名乳腺癌患者的变量。研究了人种/种族与癌症类型、分期、激素受体状态和治疗选择之间的关系。总的来说，45.5%的患者是西班牙裔（n：1566），这些患者更可能在与非洲裔美国人相似的更年轻的年龄（57岁）被诊断出来，更可能患有浸润性导管癌类型（82.7%）和三阴性疾病（17.1%，95%CI：15%至19%）。58.8%的西班牙裔（95%CI：56%至61%）有激素受体（HR）+和HER 2 −，而非西班牙裔白色人为71%。此外，西班牙裔个体表现为晚期BC（25.3%，95%CI：23%至28%），与非洲裔美国人（25.4%）相似，并且乳房肿瘤切除术比例（50%）较低，与非洲裔美国人（50%）相似。与非裔美国人患者相比，西班牙裔患者的三阴性BC患病率更高（西班牙裔患者为17.11%，非裔美国人为13.86%）。结论：西班牙裔有显着较高的相对风险，先进的阶段，在介绍（相对风险比（RRR）= 2.05，P < 0.001），三阴性肿瘤（RRR = 2.64，P < 0.0001），HER 2 + /HR −疾病（RRR = 1.77，P < 0.0001），HR+ /HER 2 − BC较少（RRR = 0.69，P < 0.0001）。西班牙裔和非洲裔美国人在较年轻时被诊断出患有乳腺癌，三阴性乳腺癌的患病率较高，并且在疾病的晚期被诊断出。提高认识和针对少数群体采取健康促进干预措施、筛查和早期发现，对于减少健康差距的负担仍然至关重要。
Breast cancer (BC) is the leading cause of cancer death in Hispanic/Latino women nationwide. Hispanic women are more likely to be presented with advanced disease and adverse prognosis subtypes. The aim of this study is to describe the clinico‐ pathological characteristics and disparities in breast cancer in this group at two tertiary care University‐based medical centers. After IRB approval, Cancer registry was used to analyze the variables of 3441 patients with breast cancer diagnosed and treated consecutively at two large tertiary University based medical and cancer center database centers in El Paso, TX and Loma Linda, CA between 2005 and 2015. Association between race/ethnicity and cancer type, stage, hormone receptor status and treatment option were investigated. Overall 45.5% of the patients were Hispanic (n: 1566) and those were more likely to be diagnosed at a younger age (57 years) similar to African Americans, more likely to have invasive ductal carcinoma type (82.7%) & triple negative disease (17.1%, 95%CI: 15% to 19%). 58.8% of Hispanics (95%CI: 56% to 61%) have hormone receptor (HR)+ & HER2− as opposed to 71% in non‐Hispanic White people. In addition, Hispanic individuals presented with advanced stages of BC (25.3%, 95% CI: 23% to 28%) similar to African American (25.4%), and had a lower proportion of lumpectomy (50%) similar to African American (50%). When compared to African American patients, Hispanic patients had a higher prevalence of triple negative BC (17.11% in Hispanics Versus 13.86% in African American). Conclusion: Hispanics had significantly higher relative risk of advanced stages at presentation (Relative Risk Ratio (RRR) = 2.05, P < 0.001), triple negative tumors (RRR = 2.64, P < 0.0001), HER2 + /HR ‐ disease (RRR = 1.77, P < 0.0001), and less HR+ /HER2− BC (RRR = 0.69, P < 0.0001). Hispanics and African Americans are diagnosed with breast cancer at a younger age, have a higher prevalence of Triple negative breast cancer, and are diagnosed at more advanced stages of disease. Increasing awareness and targeting minority populations for health promotion interventions, screening and early detection continue to be of paramount importance to reduce the burden of health disparities.
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DOI：
10.1158/1055-9965.epi-15-0293
发表时间：
2015-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Chen L;Li CI
通讯作者：
Li CI
DOI：
10.1093/jnci/djv048
发表时间：
2015-06
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Kohler BA;Sherman RL;Howlader N;Jemal A;Ryerson AB;Henry KA;Boscoe FP;Cronin KA;Lake A;Noone AM;Henley SJ;Eheman CR;Anderson RN;Penberthy L
通讯作者：
Penberthy L
DOI：
10.1186/bcr3429
发表时间：
2013-06-27
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Danforth DN Jr
通讯作者：
Danforth DN Jr
影响因子：
254.7
作者：
DeSantis, Carol E.;Fedewa, Stacey A.;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
2.1
作者：
Parise, Carol A.;Bauer, Katrina R.;Caggiano, Vincent
通讯作者：
Caggiano, Vincent