Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.
Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.
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DOI：
10.1001/jama.2009.2008
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发表时间：
2010-01-20
影响因子：
120.7
通讯作者：
Whooley, Mary A.
中科院分区：
文献类型：
--
作者：
Farzaneh-Far, Ramin;Lin, Jue;Epel, Elissa S.;Harris, William S.;Blackburn, Elizabeth H.;Whooley, Mary A.
海洋欧米茄-3脂肪酸的饮食摄入量增加与冠心病患者的生存期延长有关。然而，这种保护作用的机制知之甚少。研究血液中omega-3脂肪酸水平与端粒长度（一种新兴的生物学年龄标志物）时间变化的关系。前瞻性队列研究，纳入了2000年9月至2002年12月期间从心脏和灵魂研究招募的608例加州稳定型冠状动脉疾病门诊患者，随访至2009年1月（中位数，6.0年;范围，5.0-8.1年）。我们在基线时测量白细胞端粒长度，并在随访5年后再次测量。多变量线性和逻辑回归模型被用来研究ω-3脂肪酸（二十二碳六烯酸[DHA]和二十碳五烯酸[EPA]）的基线水平与随后端粒长度变化的相关性。DHA 3 EPA最低四分位数的个体端粒缩短速度最快（5年内端粒与单拷贝基因比值[T/S]单位为0.13; 95%置信区间[CI]为0.09-0.17），而那些处于最高四分位数的人端粒缩短的速度最慢（5年内0.05 T/S单位; 95% CI，0.02-0.08;四分位数线性趋势P<0.001）。DHA+EPA水平与端粒缩短较少相关，在对已确定的风险因素和潜在混杂因素进行序贯校正之前（未校正的β系数× 10−3=0.06; 95%CI，0.02-0.10）和之后（校正的β系数× 10−3=0.05; 95%CI，0.01-0.08）。DHA+EPA水平每增加1-SD，端粒缩短的几率就会降低32%（调整后的比值比，0.68; 95%CI，0.47-0.98）。在这组冠心病患者中，海洋omega-3脂肪酸的基线血液水平与5年内端粒缩短率之间呈反比关系。
Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood. To investigate the association of omega-3 fatty acid blood levels with temporal changes in telomere length, an emerging marker of biological age. Prospective cohort study of 608 ambulatory outpatients in California with stable coronary artery disease recruited from the Heart and Soul Study between September 2000 and December 2002 and followed up to January 2009 (median, 6.0 years; range, 5.0-8.1 years). We measured leukocyte telomere length at baseline and again after 5 years of follow-up. Multivariable linear and logistic regression models were used to investigate the association of baseline levels of omega-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) with subsequent change in telomere length. Individuals in the lowest quartile of DHA3EPA experienced the fastest rate of telomere shortening (0.13 telomere-to-single-copy gene ratio [T/S] units over 5 years; 95% confidence interval [CI], 0.09-0.17), whereas those in the highest quartile experienced the slowest rate of telomere shortening (0.05 T/S units over 5 years; 95% CI, 0.02-0.08; P<.001 for linear trend across quartiles). Levels of DHA+EPA were associated with less telomere shortening before (unadjusted β coefficient × 10−3=0.06; 95% CI, 0.02-0.10) and after (adjusted β coefficient × 10−3=0.05; 95% CI, 0.01-0.08) sequential adjustment for established risk factors and potential confounders. Each 1-SD increase in DHA+EPA levels was associated with a 32% reduction in the odds of telomere shortening (adjusted odds ratio, 0.68; 95% CI, 0.47-0.98). Among this cohort of patients with coronary artery disease, there was an inverse relationship between baseline blood levels of marine omega-3 fatty acids and the rate of telomere shortening over 5 years.
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DOI：
10.3945/ajcn.2009.27580
发表时间：
2009-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Albanese E;Dangour AD;Uauy R;Acosta D;Guerra M;Guerra SS;Huang Y;Jacob KS;de Rodriguez JL;Noriega LH;Salas A;Sosa AL;Sousa RM;Williams J;Ferri CP;Prince MJ
通讯作者：
Prince MJ
影响因子：
7.1
作者：
Harris, William S.
通讯作者：
Harris, William S.
影响因子：
158.5
作者：
Albert, CM;Campos, H;Ma, J
通讯作者：
Ma, J
DOI：
10.1016/j.bbalip.2005.08.017
发表时间：
2005-10-15
影响因子：
4.8
作者：
Eitsuka, T;Nakagawa, K;Miyazawa, T
通讯作者：
Miyazawa, T
DOI：
10.1098/rstb.2003.1370
发表时间：
2004-01-29
影响因子：
6.3
作者：
Chan, SRWL;Blackburn, EH
通讯作者：
Blackburn, EH