Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015-2018 Behavioral Risk Factor Surveillance System Survey.
Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015-2018 Behavioral Risk Factor Surveillance System Survey.
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DOI：
10.1186/s13293-022-00425-3
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发表时间：
2022-04-12
影响因子：
7.9
通讯作者：
Qeadan, Fares
中科院分区：
文献类型：
--
作者：
Schliep, Karen C.;Barbeau, William A.;Lynch, Kristine E.;Sorweid, Michelle K.;Varner, Michael W.;Foster, Norman L.;Qeadan, Fares
关键词：
先前的研究表明，至少35%的阿尔茨海默病和相关的痴呆症风险可能是可以预防的。主观认知能力下降通常是临床前痴呆的第一个迹象，在这类人中，女性患阿尔茨海默病的风险比男性更大。我们希望了解可修改因素如何与主观认知下降相关，以及性别是否存在差异。数据收集自完成美国行为风险因素监测系统认知下降模块(2015年-2018年)的男性和女性(45岁及以上)，n = 216,838。我们计算了以下因素的主观认知下降的人群归因比例，按性别分层：教育程度有限、耳聋、社交孤立、抑郁、吸烟、缺乏体育活动、肥胖、高血压和糖尿病。我们的模型根据年龄、种族、收入、就业、婚姻和退伍军人状况进行了调整，并考虑了风险因素之间的共同性。最终的研究样本包括比男性更多的女性(53.7%)，但两者都有类似的主观认知下降的患病率(10.6%的女性对11.2%的男性)。女性和男性解释主观认知下降的总体人口归因比例几乎相同(女性39.7%，男性41.3%)。前三位的危险因素是社会孤立、抑郁和高血压，这解释了总体人口归因率的四分之三。虽然我们没有发现男性和女性之间在导致主观认知下降的可修改因素方面的任何差异，但其他因素，包括生殖或内分泌健康史或与性别相互作用以修改风险的生物因素，值得进一步研究。网上版载有补充材料，可在10.1186/s13293-022-00425-3查阅。主观认知功能减退(SCD)是阿尔茨海默病及相关痴呆最早出现的明显症状之一。虽然目前还没有治愈痴呆症的方法，但研究表明，至少35%的痴呆症风险可以通过在认知能力下降临床明显之前几年甚至几十年减少暴露而改变。先前的研究表明，有认知障碍的人患痴呆症的风险女性高于男性，患痴呆症的总体风险也是如此。在全国具有代表性的20多万成年人中，年龄在45岁及以上的SCD患病率为11%，女性和男性都是如此。女性和男性解释主观认知下降的总体人口归因比例也几乎相同(女性为39.7%，男性为41.3%)。女性和男性的前三大危险因素都是社会孤立、抑郁和高血压，这解释了总体人口归因率的四分之三。网上版载有补充材料，可在10.1186/s13293-022-00425-3查阅。
Prior research indicates that at least 35% of Alzheimer’s disease and related dementia risk may be amenable to prevention. Subjective cognitive decline is often the first indication of preclinical dementia, with the risk of subsequent Alzheimer’s disease in such individuals being greater in women than men. We wished to understand how modifiable factors are associated with subjective cognitive decline, and whether differences exist by sex. Data were collected from men and women (45 years and older) who completed the U.S. Behavioral Risk Factor Surveillance System Cognitive Decline Module (2015–2018), n = 216,838. We calculated population-attributable fractions for subjective cognitive decline, stratified by sex, of the following factors: limited education, deafness, social isolation, depression, smoking, physical inactivity, obesity, hypertension, and diabetes. Our models were adjusted for age, race, income, employment, marital and Veteran status, and accounted for communality among risk factors. The final study sample included more women (53.7%) than men, but both had a similar prevalence of subjective cognitive decline (10.6% of women versus 11.2% of men). Women and men had nearly equivalent overall population-attributable fractions to explain subjective cognitive decline (39.7% for women versus 41.3% for men). The top three contributing risk factors were social isolation, depression, and hypertension, which explained three-quarters of the overall population-attributable fraction. While we did not identify any differences in modifiable factors between men and women contributing to subjective cognitive decline, other factors including reproductive or endocrinological health history or biological factors that interact with sex to modify risk warrant further research. The online version contains supplementary material available at 10.1186/s13293-022-00425-3. Subjective Cognitive Decline (SCD) is one of the earliest noticeable symptoms of Alzheimer’s disease and related dementias. While there is no current cure for dementia, research indicates that at least 35% of dementia risk may be modifiable by decreasing exposures years or even decades before cognitive decline becomes clinically evident. Prior research has shown that the risk of dementia in individuals with cognitive impairment is higher in women than in men, as is the overall risk of dementia. Among a nationally representative population of over 200,000 adults, ages 45 years and older, SCD prevalence was 11% for both women and men. Women and men also had nearly equivalent overall population-attributable fractions to explain subjective cognitive decline (39.7% for women versus 41.3% for men). The top three contributing risk factors for both women and men were social isolation, depression, and hypertension, which explained three-quarters of the overall population-attributable fraction. The online version contains supplementary material available at 10.1186/s13293-022-00425-3.
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影响因子：
3.1
作者：
Conde DM;Verdade RC;Valadares ALR;Mella LFB;Pedro AO;Costa-Paiva L
通讯作者：
Costa-Paiva L
影响因子：
17.7
作者：
Bartels, Claudia;Wagner, Michael;Schneider, Anja
通讯作者：
Schneider, Anja
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
6.7
作者：
Mitchell, A. J.;Beaumont, H.;Stubbs, B.
通讯作者：
Stubbs, B.
影响因子：
4.6
作者：
Diaz-Galvan P;Ferreira D;Cedres N;Falahati F;Hernández-Cabrera JA;Ames D;Barroso J;Westman E
通讯作者：
Westman E