Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level.
Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level.
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人口平均T2 MRI图揭示了随着腰椎水平而变化的兔椎间盘的定量区域转变。
DOI：
10.1002/jor.22737
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发表时间：
2015-01
影响因子：
2.8
通讯作者：
Smith, Harvey E.
中科院分区：
文献类型：
--
作者：
Martin, John T.;Collins, Christopher M.;Ikuta, Kensuke;Mauck, Robert L.;Elliott, Dawn M.;Zhang, Yeija;Anderson, D. Greg;Vaccaro, Alexander R.;Albert, Todd J.;Arlet, Vincent;Smith, Harvey E.
常规进行T2加权磁共振成像（MRI）以评估椎间盘退变。然而，MR图像的标准临床评价是定性的，并且不关注椎间盘的区域特异性改变。利用兔针穿刺模型，T2映射进行损伤的椎间盘，发展穿刺后的退行性过程的定量描述。为此，将18 G针插入每只兔的四个椎间盘（L3/L4至L 6/L7），并在损伤前和损伤后4周生成T2图。将单个T2图归一化到椎间盘特异性坐标系，然后对损伤前和损伤后人群复合T2图进行平均。我们还开发了一种方法来自动分割髓核的二维和三维曲线拟合例程。穿刺损伤以反映人类变性的区域特异性方式产生MR信号强度的改变。群体平均T2图提供了损伤反应的定量表示，并确定了个体退变椎间盘与损伤前群体的偏差。我们发现，在较低的腰椎节段，标准化损伤的反应是适度的，可能是椎间盘尺寸增加的结果。这些工具将是有价值的定量表征椎间盘退变在未来的临床和临床前研究。
Magnetic resonance imaging (MRI) with T2-weighting is routinely performed to assess intervertebral disc degeneration. Standard clinical evaluations of MR images are qualitative, however, and do not focus on region-specific alterations in the disc. Utilizing a rabbit needle puncture model, T2 mapping was performed on injured discs to develop a quantitative description of the degenerative process following puncture. To do so, an 18G needle was inserted into four discs per rabbit (L3/L4 to L6/L7) and T2 maps were generated pre- and 4 weeks post-injury. Individual T2 maps were normalized to a disc-specific coordinate system and then averaged for pre- and post-injury population composite T2 maps. We also developed a method to automatically segment the nucleus pulposus by 2-D and 3-D curve fitting routines. Puncture injury produced alterations in MR signal intensity in a region-specific manner mirroring human degeneration. Population average T2 maps provided a quantitative representation of the injury response, and identified deviations of individual degenerate discs from the pre-injury population. We found that the response to standardized injury was modest at lower lumbar levels, likely as a result of increased disc dimensions. These tools will be valuable for the quantitative characterization of disc degeneration in future clinical and pre-clinical studies.
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DOI：
10.1002/jor.22355
发表时间：
2013-08
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Martin JT;Gorth DJ;Beattie EE;Harfe BD;Smith LJ;Elliott DM
通讯作者：
Elliott DM
影响因子：
19.7
作者：
AGUILA, LA;PIRAINO, DW;WEINSTEIN, MA
通讯作者：
WEINSTEIN, MA
DOI：
10.1016/j.spinee.2006.04.014
发表时间：
2006-11-01
期刊：
The spine journal : official journal of the North American Spine Society
影响因子：
--
作者：
Miyamoto, Kei;Masuda, Koichi;An, Howard S
通讯作者：
An, Howard S
影响因子：
4.5
作者：
Gregory, Diane E.;Bae, Won C.;Masuda, Koichi
通讯作者：
Masuda, Koichi
影响因子：
--
作者：
Mosher, TJ;Liu, Y;Smith, MB
通讯作者：
Smith, MB