Plant biosynthetic gene clusters in the context of metabolic evolution.
Plant biosynthetic gene clusters in the context of metabolic evolution.
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在代谢进化的背景下,植物生物合成基因簇。
DOI:
10.1039/d2np00005a
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发表时间:
2022-07-20
影响因子:
11.9
通讯作者:
Lichman BR
中科院分区:
文献类型:
--
作者:
Smit SJ;Lichman BR
Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically diverse natural products to interact with their environment. These specialised metabolites typically evolve in limited taxonomic groups presumably in response to specific selective pressures. With the increasing availability of sequencing data, it has become apparent that in many cases the genes encoding biosynthetic enzymes for specialised metabolic pathways are not randomly distributed on the genome. Instead they are physically linked in structures such as arrays, pairs and clusters. The exact function of these clusters is debated. In this review we take a broad view of gene arrangement in plant specialised metabolism, examining types of structures and variation. We discuss the evolution of biosynthetic gene clusters in the wider context of metabolism, populations and epigenetics. Finally, we synthesise our observations to propose a new hypothesis for biosynthetic gene cluster formation in plants. A significant subset of plant specialised metabolism genes are arranged in biosynthetic gene clusters. Here, we review these clusters and discuss their possible roles within the context of genome dynamics and metabolic evolution.
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