Nerve growth factor (NGF) receptor expression in chicken cranial development
Nerve growth factor (NGF) receptor expression in chicken cranial development
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鸡颅骨发育中神经生长因子（NGF）受体的表达
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
A. Sutter
中科院分区：
文献类型：
--
作者：
G. Raivich;A. Zimmermann;A. Sutter
为定位鸡脑和颅神经节发育过程中神经生长因子（NGF）受体的表达，以125 I β-NGF为探针，对鸡胚胎第3天（E3）至孵化后第3天（P3）的发育过程进行了放射自显影分析。在整个发育过程中和孵化后，在经典的NGF靶位点、近端颅感觉神经节和交感上级颈神经节观察到重放射自显影标记。与此相反，只有弱标记可以检测到在有限的时间跨度在前庭耳蜗（E4-E8）和远端颅感觉神经节（E4-E10），其中的神经元起源于耳和鳃上基板。在早期脑发育过程中，在不同脑区也观察到特异性125 b β 3 NGF结合。神经生长因子受体的表达有一个特征性的模式。神经上皮层显示非常低水平的特异性125 Ib <$NGF结合，而在套层中发现强烈的125 Ib <$NGF标记。发现在早期发育（E4-E12）中，脑干体动核、内脏柱、脑干背板、小脑原基、顶盖和基底前脑（上丘脑、纹状体）被125 Ib NGF短暂标记。还标记了非神经组织，如耳泡上皮部分和头部骨骼肌原基。这些结果表明，125 Ib NGF与不同来源的颅细胞（神经管、神经嵴、基板和可能的中胚层）特异性结合，加强了NGF在各种组织和细胞类型的生长和分化中可能具有不同功能的概念。
In order to map the expression of receptors for nerve growth factor (NGF) during brain and cranial ganglia development, iodinated NGF (125IβNGF) was used as a probe in an autoradiographical analysis performed between embryonic day 3 (E3) and posthatching day 3 (P3) of chicken development. Heavy autoradiographic labelling was observed at the classical NGF target sites, the proximal cranial sensory ganglia and the sympathetic superior cervical ganglion, throughout development and after hatching. In contrast, only weak Labelling could be detected during a restricted time span in the vestibulocochlear (E4–E8) and the distal cranial sensory ganglia (E4–E10), the neurons of which originate from the otic and epibranchial placodes. Specific 125b̃3NGF binding was also observed in various brain regions during early brain development. NGF receptor expression there followed a characteristic pattern. The neuroepithelial layer displayed very low levels of specific 125Ib̃NGF binding, while strong 125Ib̃NGF labelling was found in the mantle layer. Brainstem somatomotor nuclei, visceromotor columns, brain‐stem alar plate, cerebellar anlage, tectum, and basal forebrain (epithalamus, striatum) were found to be transiently labelled by 125Ib̃NGF in early development (E4–E12). Non‐nervous tissues such as parts of the otic vesicle epithelium and skeletal muscle anlagen of the head were also labelled. These results, showing specific binding of 125Ib̃NGF to cranial cells of different origin (neural tube, neural crest, placode, and possibly mesoderm) strengthen the concept that NGF may have diverse functions in growth and differentiation of various tissues and cell types.
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影响因子：
2.7
作者：
Pearson,J;Johnson,EM;Brandeis,L
通讯作者：
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DOI：
10.1126/science.2861660
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
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