Suppression of ipsilateral motor cortex facilitates motor skill learning.
Suppression of ipsilateral motor cortex facilitates motor skill learning.
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DOI：
10.1111/j.1460-9568.2009.06628.x
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Pascual-Leone A
中科院分区：
文献类型：
--
作者：
Kobayashi M;Théoret H;Pascual-Leone A
The primary motor cortex (M1) plays a critical role in early aspects of motor skill learning. Given the notion of inter-hemispheric competition, unilateral disruption of M1 may increase excitability of the unaffected motor cortex and thus improve motor learning with the ipsilateral hand. We applied slow-frequency repetitive transcranial magnetic stimulation (rTMS) before the initiation of practice of a simple motor skill. Participants were randomly divided into three stimulation groups: i) ipsilateral M1; ii) contralateral M1; and Cz (control site). Mean execution time and error rate were recorded in 4 sessions distributed over 2 days. Disruption of M1 with rTMS slowed down skill acquisition with the contralateral hand, but paradoxically enhanced learning with the ipsilateral hand. This was evidenced by a significant decrease of execution time at the end of day 1 in the group that received rTMS over the ipsilateral M1 compared to both control groups (Cz and contralateral M1 stimulation). This supports the notion of inter-hemispheric competition and provides novel insights that may be applicable to neurorehabilitation.
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