Co-occurring obsessive-compulsive disorder and autism spectrum disorder in young people: prevalence, clinical characteristics and outcomes.
Co-occurring obsessive-compulsive disorder and autism spectrum disorder in young people: prevalence, clinical characteristics and outcomes.
复制标题
DOI：
10.1007/s00787-020-01478-8
复制
发表时间：
2020-11
影响因子：
6.4
通讯作者：
Krebs G
中科院分区：
文献类型：
--
作者：
Martin AF;Jassi A;Cullen AE;Broadbent M;Downs J;Krebs G
强迫症（OCD）和自闭症谱系障碍（ASD）通常同时发生，并且当它们在青年中同时发生时被认为具有挑战性。然而，这组的临床特征和预后仍然知之甚少。本研究在一个大型临床队列中检查了儿童强迫症与ASD（强迫症+ ASD）并存的患病率、临床相关性和结局。数据提取自英国南伦敦参加精神健康信托的4-17岁年轻人的电子临床记录。我们确定了被诊断为OCD + ASD（n = 335），OCD不伴ASD（n = 1010）和ASD不伴OCD（n = 6577）的年轻人。25%的强迫症青年被诊断为ASD，而5%的ASD青年被诊断为强迫症。在诊断时，与强迫症或ASD患者相比，患有强迫症+ ASD的青少年在临床医生评定的儿童总体评估量表（CGAS）上的心理社会功能评分较低。与强迫症+ ASD的青少年相比，强迫症+ ASD的青少年接受CBT的可能性相同，但更有可能比任何一个对照组更长时间地服用处方药和使用服务。患有强迫症+ ASD的青少年在使用服务后表现出功能（CGAS评分）的显着改善，但他们的收益小于强迫症患者。强迫症+ ASD通常共同发生，赋予实质性的损害，尽管强迫症可能在ASD青年中诊断不足。患有共同发生的强迫症+ ASD的年轻人可以在常规临床护理中显着改善功能，但可能比通常患有强迫症的年轻人受损更严重，这表明需要为这些年轻人提供长期支持。本文的在线版本（10.1007/s 00787 -020-01478-8）包含补充材料，可供授权用户使用。
Obsessive–compulsive disorder (OCD) and autism spectrum disorders (ASD) commonly co-occur and are considered challenging to manage when they co-occur in youth. However, clinical characteristics and prognosis of this group remain poorly understood. This study examined the prevalence, clinical correlates and outcomes of paediatric OCD co-occurring with ASD (OCD + ASD) in a large clinical cohort. Data were extracted from electronic clinical records of young people aged 4–17 years who had attended a mental health trust in South London, United Kingdom. We identified young people with diagnoses of OCD + ASD (n = 335), OCD without ASD (n = 1010), and ASD without OCD (n = 6577). 25% of youth with OCD had a diagnosis of ASD, while 5% of those with ASD had a diagnosis of OCD. At diagnosis, youth with OCD + ASD had lower psychosocial functioning scores on the clinician-rated Child Global Assessment Scale (CGAS) compared to those with either OCD or ASD. Youth with OCD + ASD were equally likely to receive CBT compared to those with OCD but were more likely to be prescribed medication and use services for longer than either comparison group. Youth with OCD + ASD showed significant improvements in functioning (CGAS scores) after service utilisation but their gains were smaller than those with OCD. OCD + ASD commonly co-occur, conferring substantial impairment, although OCD may be underdiagnosed in youth with ASD. Young people with co-occurring OCD + ASD can make significant improvements in functioning with routine clinical care but are likely to remain more impaired than typically developing youth with OCD, indicating a need for longer-term support for these young people. The online version of this article (10.1007/s00787-020-01478-8) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
3.7
作者：
Wood JJ;Ehrenreich-May J;Alessandri M;Fujii C;Renno P;Laugeson E;Piacentini JC;De Nadai AS;Arnold E;Lewin AB;Murphy TK;Storch EA
通讯作者：
Storch EA
影响因子：
4.4
作者：
Stewart, Robert;Soremekun, Mishael;Lovestone, Simon
通讯作者：
Lovestone, Simon
影响因子：
2.9
作者：
Downs, Johnny M.;Ford, Tamsin;Hayes, Richard
通讯作者：
Hayes, Richard
影响因子：
2.5
作者：
Mazefsky, C. A.;Kao, J.;Oswald, D. P.
通讯作者：
Oswald, D. P.
影响因子：
3.9
作者：
Zandt, Fiona;Prior, Margot;Kyrios, Michael
通讯作者：
Kyrios, Michael