Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis.

Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis.
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DOI:
10.1186/2049-2618-1-29
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发表时间:
2013-12-02
期刊:
影响因子:
15.5
通讯作者:
Forney LJ
Forney LJ
中科院分区:
生物学1区
文献类型:
--
作者:
Ravel J;Brotman RM;Gajer P;Ma B;Nandy M;Fadrosh DW;Sakamoto J;Koenig SS;Fu L;Zhou X;Hickey RJ;Schwebke JR;Forney LJ

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细菌性阴道病(BV)是一种常见的妇科诊断,其特征是阴道微生物群的生态失调。它通常伴有阴道症状,如气味和分泌物,但可能无症状。尽管经过50多年的研究,BV的病因仍不清楚,这是治疗和预防BV的主要障碍。在这里,我们报告了10周内25个阴道群落的时间动态,使用每天从诊断为有症状的BV(15名女性),无症状的BV(6名女性)和没有BV的女性(4名女性)中收集的样本。这种独特的样本和数据资源将有助于更好地了解阴道微生物在BV自然史中的作用,并改善诊断和治疗。
Bacterial vaginosis (BV) is a common gynecologic diagnosis characterized by dysbiosis of the vaginal microbiota. It is often accompanied by vaginal symptoms such as odor and discharge, but can be asymptomatic. Despite over 50 years of research, the etiology of BV is not well understood, which is a major impediment to treatment and prevention of BV. Here we report on the temporal dynamics of 25 vaginal communities over a 10 week period using samples collected daily from women who were diagnosed with symptomatic BV (15 women), asymptomatic BV (6 women), and women who did not have BV (4 women). This unique resource of samples and data will contribute to a better understanding of the role that the vaginal microbes have in the natural history of BV and lead to improved diagnosis and treatment.
细菌性阴道病女性的细菌群落:高分辨率系统发育分析揭示了微生物群与临床标准的关系。
DOI: 10.1371/journal.pone.0037818
发表时间: 2012
期刊: PloS one
影响因子: 3.7
作者:
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