Caenorhabditis elegans pheromones regulate multiple complex behaviors.

Caenorhabditis elegans pheromones regulate multiple complex behaviors.
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DOI:
10.1016/j.conb.2009.07.007
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发表时间:
2009-08
影响因子:
5.7
通讯作者:
Edison AS
Edison AS
中科院分区:
医学2区
文献类型:
--
作者:
Edison AS

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一种名为蛔虫苷的小分子家族作为信息素控制线虫线虫的多种行为。在皮摩尔浓度下,两性生物产生的至少三种蛔虫苷的协同混合物会引起雄性特有的吸引。在较高的浓度下,相同的芦荟苷,可能是不同的混合物,会导致发育停滞阶段,即所谓的达尔。蛔虫苷的生产强烈依赖于环境条件,尽管人们对其调节的主要变量和机制知之甚少。因此,雄性交配和达尔的形成是通过一组共同的小分子联系在一起的,这些小分子的表达对给定的微环境很敏感,这表明了一种模式,通过这种模式,蛔虫苷调控了线虫的整个生命周期。
A family of small molecules called ascarosides act as pheromones to control multiple behaviors in the nematode Caenorhabditis elegans. At picomolar concentrations, a synergistic mixture of at least three ascarosides produced by hermaphrodites causes male-specific attraction. At higher concentrations, the same ascarosides, perhaps in a different mixture, induce the developmentally arrested stage known as dauer. The production of ascarosides is strongly dependent on environmental conditions, although relatively little is known about the major variables and mechanisms of their regulation. Thus, male mating and dauer formation are linked through a common set of small molecules whose expression is sensitive to a given microenvironment, suggesting a model by which ascarosides regulate the overall life cycle of C. elegans.
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