Deficient proactive interference of eyeblink conditioning in Wistar-Kyoto rats.
Deficient proactive interference of eyeblink conditioning in Wistar-Kyoto rats.
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DOI：
10.1016/j.bbr.2010.07.005
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Servatius, Richard J.
中科院分区：
文献类型：
--
作者：
Ricart, Thomas M.;De Niear, Matthew A.;Jiao, Xilu;Pang, Kevin C. H.;Beck, Kevin D.;Servatius, Richard J.
关键词：
Wistar京都（WKY）大鼠表现出行为抑制和模型焦虑脆弱性。虽然WKY大鼠表现出更快的主动回避收购，简单的联想学习或积极干预（PI）的影响还没有得到充分的评估，在这个应变。因此，我们评估了WKY和远交Sprague道利（SD）大鼠的眨眼条件反射和PI。将大鼠预先暴露于实验情境、条件刺激（CS）、无条件刺激（US）或CS & US（EUP）中，分别检测潜伏抑制（LI）、US预暴露效应和学习无关性（LIRR）。在预暴露后，立即在延迟型范例（500 ms CS coterminating与10 ms US）中训练大鼠一次。在训练过程中，SD大鼠表现出LI和抑制从US预暴露没有LIRR的证据。PI在WKY大鼠中不太明显; LI在WKY大鼠中不存在。即使在单独CS和单独US预暴露的PI降低的情况下，LIRR在WKY大鼠中也不明显。WKY大鼠在SD大鼠表现降低的条件下表现出的更正常的获得率增加了WKY大鼠获得防御反应的总体可能性。增强防御反应的获得是焦虑脆弱性（例如，行为抑制）被转化为焦虑精神病理学。
Wistar Kyoto (WKY) rats exhibit behavioral inhibition and model anxiety vulnerability. Although WKY rats exhibit faster active avoidance acquisition, simple associative learning or the influence of proactive interference (PI) has not been adequately assessed in this strain. Therefore, we assessed eyeblink conditioning and PI in WKY and outbred Sprague Dawley (SD) rats. Rats were pre-exposed to either the experimental context, the conditioned stimulus (CS), the unconditional stimulus (US), or the CS & US in an explicitly unpaired (EUP) manner, to examine latent inhibition (LI), US pre-exposure effect, or learned irrelevance (LIRR), respectively. Immediately following pre-exposures, rats were trained in a delay-type paradigm (500 ms CS coterminating with a 10-ms US) for one session. During training SD rats exhibited LI and inhibition from US pre-exposures without evidence of LIRR. PI was less evident in WKY rats; LI was absent in WKY rats. Even in the context of reduced PI to CS-alone and US-alone pre-exposures, LIRR was not apparent in WKY rats. The more normal acquisition rates exhibited by WKY rats, under conditions which degrade performance in SD rats, increases the overall likelihood for WKY rats to acquire defensive responses. Enhanced acquisition of defensive responses is a means by which anxiety vulnerability (e.g., behavioral inhibition) is translated to anxiety psychopathology.
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DOI：
10.1080/02724990244000197
发表时间：
2003-02-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
Baker, AG;Murphy, RA;Mehta, R
通讯作者：
Mehta, R
影响因子：
10.6
作者：
Malkesman, O;Braw, Y;Weller, A
通讯作者：
Weller, A
影响因子：
2.9
作者：
Jiao, X;Paré, WP;Tejani-Butt, SM
通讯作者：
Tejani-Butt, SM
DOI：
10.1037/0097-7403.22.2.183
发表时间：
1996-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
Bonardi, C;Hall, G
通讯作者：
Hall, G
影响因子：
7.4
作者：
Gladstone, GL;Parker, GB;Malhi, GS
通讯作者：
Malhi, GS