Symptoms of anxiety/depression is associated with more aggressive inflammatory bowel disease.
Symptoms of anxiety/depression is associated with more aggressive inflammatory bowel disease.
复制标题
焦虑/抑郁症状与更具侵袭性的炎症性肠病有关
DOI：
10.1038/s41598-021-81213-8
复制
发表时间：
2021-01-14
影响因子：
4.6
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Gao X;Tang Y;Lei N;Luo Y;Chen P;Liang C;Duan S;Zhang Y
研究表明，炎症性肠病(IBD)患者患焦虑和/或抑郁的风险增加。有抑郁/焦虑的IBD患者的住院率和疾病严重性比没有抑郁/焦虑的患者更高。到目前为止，关于焦虑/抑郁对中国IBD患者的影响的数据还很少。本研究的目的是了解中国IBD人群焦虑/抑郁症状的患病率及其对IBD相关特征的影响。这是一项来自西南地区中国肠易激综合征转诊中心的横断面研究。符合条件的参与者根据医院焦虑和抑郁量表(HADS)被分为有焦虑/抑郁症状的人和没有焦虑/抑郁症状的人。比较两组的人口学数据和病程、IBD相关手术、吸烟、肠外表现、疾病活动性评分、内窥镜评估、实验室数据和当前用药情况。共纳入341例IBD患者，包括221例克罗恩病(CD)和120例溃疡性结肠炎(UC)。IBD患者焦虑/抑郁症状的发生率为33.1%。有焦虑/抑郁症状的CD患者在单纯内窥镜下克罗恩病评分(SES-CD)上得分较高(p = 0.0005)。有焦虑/抑郁症状的UC患者的Mayo评分(p = 0.0017)和溃疡性结肠炎严重程度指数(UCEIS)(p <； 0.0001)显著高于无焦虑/抑郁症状的患者。CD相关手术(p = 0.012)和克罗恩疾病活动指数(p <； 0.0001)是CD焦虑/抑郁症状的独立危险因素，而皮质类固醇的使用(p = 0.036)是UC焦虑/抑郁症状的独立危险因素。本研究有助于我们了解IBD患者焦虑/抑郁症状的发生率及其对IBD病程的影响，提醒我们更多地关注IBD合并焦虑/抑郁的处理。
Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impact of anxiety/depression on Chinese IBD patients. The aim of this study was to find out the prevalence of symptoms of anxiety/depression in Chinese IBD population and its impact on IBD-related features. This is a cross-sectional study from the southwest China IBD referral center. Eligible participants were divided into those with symptoms of anxiety/depression and those without based on the Hospital Anxiety and Depression Scale (HADS). Demographic data and disease duration, IBD-related surgery, tobacco use, extra-intestinal manifestations, disease activity scores, endoscopic evaluation, laboratory data and current medication use were compared between two groups. A total of 341 IBD patients [221 Crohn’s disease (CD) and 120 ulcerative colitis (UC)] were included. The prevalence of symptoms of anxiety/depression in IBD was 33.1%. CD patients with symptoms of anxiety/depression tended to have higher scores of simple endoscopic scores for Crohn’s disease (SES-CD) (p = 0.0005). UC patients with symptoms of anxiety/depression had a significantly higher Mayo score (p = 0.0017) and ulcerative colitis endoscopic index of severity (UCEIS) (p < 0.0001) than their non-anxiety/depression counterparts. CD-related surgery (p = 0.012) and Crohn's disease activity index (CDAI) (p < 0.0001) were identified as independent risk factors for symptoms of anxiety/depression in CD, while corticosteroid use (p = 0.036) as an independent risk factor for symptoms of anxiety/depression in UC. This study helps our understanding of the prevalence of symptoms of anxiety/depression in IBD patients and its impact on IBD course and reminds us to pay more attention on IBD management with anxiety/depression.
登录
查看更多内容
中国人群炎症性肠病的疾病负担和临床特征：系统评价和荟萃分析
DOI：
10.3390/ijerph14030238
发表时间：
2017-02-28
影响因子：
--
作者：
Li X;Song P;Li J;Tao Y;Li G;Li X;Yu Z
通讯作者：
Yu Z
影响因子：
4.9
作者：
Lewis, Kylee;Marrie, Ruth Ann;Marriott, James
通讯作者：
Marriott, James
影响因子：
10.5
作者：
SHEFFIELD, BF;CARNEY, MWP
通讯作者：
CARNEY, MWP
影响因子：
4.9
作者：
Engel, Tal;Ben-Horin, Shomron;Beer-Gabel, Marc
通讯作者：
Beer-Gabel, Marc
DOI：
10.1111/j.1440-1746.2006.04140.x
发表时间：
2006-06-01
影响因子：
4.1
作者：
Ran, Zhihua;Xiao, Shudong;Li, Yanqing
通讯作者：
Li, Yanqing