A supergene determines highly divergent male reproductive morphs in the ruff.
A supergene determines highly divergent male reproductive morphs in the ruff.
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DOI：
10.1038/ng.3443
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发表时间：
2016-01
期刊：
影响因子：
30.8
通讯作者：
Burke, Terry
中科院分区：
文献类型：
--
作者：
Kuepper, Clemens;Stocks, Michael;Risse, Judith E.;dos Remedios, Natalie;Farrell, Lindsay L.;Mcrae, Susan B.;Morgan, Tawna C.;Karlionova, Natalia;Pinchuk, Pavel;Verkuil, Yvonne I.;Kitaysky, Alexander S.;Wingfield, John C.;Piersma, Theunis;Zeng, Kai;Slate, Jon;Blaxter, Mark;Lank, David B.;Burke, Terry
在河豚(Philomachus Pugnax)身上，三种截然不同的另类雄性交配形态(好斗的“独立的”、半合作的“卫星”和模仿雌性的“Feders”)以平衡的多态共存。在体型、纹饰、攻击性和交配行为上的主要差异是常染色体遗传的。我们表明，卫星和Feders的发育是由一个超基因决定的，该超基因由11号染色体上倒位的发散、显性、非重组单倍型组成，该倒位包含125个预测基因。对于祖先序列来说，独立基因是纯合的。倒位的一个断裂点破坏了基本着丝粒蛋白N(CENP-N)基因，家系分析证实了倒位纯合子的致死性。我们描述了不同形态之间新的行为、睾丸大小和类固醇代谢差异，并确定了倒位中可能导致不同形态生殖特征差异的多态基因。
Three strikingly different alternative male mating morphs (aggressive “Independents”, semi-cooperative “Satellites” and female mimic “Faeders”) coexist as a balanced polymorphism in the ruff, Philomachus pugnax, a lek-breeding wading bird. Major differences in body size, ornamentation, and aggressive and mating behaviour are inherited as an autosomal polymorphism. We show that development into Satellites and Faeders is determined by a supergene consisting of divergent alternative, dominant, non-recombining haplotypes of an inversion on chromosome 11, which contains 125 predicted genes. Independents are homozygous for the ancestral sequence. One breakpoint of the inversion disrupts the essential Centromere protein N (CENP-N) gene, and pedigree analysis confirms lethality of inversion homozygotes. We describe novel behavioural, testes size, and steroid metabolic differences among morphs, and identify polymorphic genes within the inversion that are likely to contribute to the differences among morphs in reproductive traits.
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影响因子：
21.3
作者：
Carroll, Christopher W.;Silva, Mariana C. C.;Godek, Kristina M.;Jansen, Lars E. T.;Straight, Aaron F.
通讯作者：
Straight, Aaron F.
影响因子：
3.7
作者：
Baird NA;Etter PD;Atwood TS;Currey MC;Shiver AL;Lewis ZA;Selker EU;Cresko WA;Johnson EA
通讯作者：
Johnson EA
DOI：
10.1126/science.1253451
发表时间：
2014-12-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jarvis ED;Mirarab S;Aberer AJ;Li B;Houde P;Li C;Ho SY;Faircloth BC;Nabholz B;Howard JT;Suh A;Weber CC;da Fonseca RR;Li J;Zhang F;Li H;Zhou L;Narula N;Liu L;Ganapathy G;Boussau B;Bayzid MS;Zavidovych V;Subramanian S;Gabaldón T;Capella-Gutiérrez S;Huerta-Cepas J;Rekepalli B;Munch K;Schierup M;Lindow B;Warren WC;Ray D;Green RE;Bruford MW;Zhan X;Dixon A;Li S;Li N;Huang Y;Derryberry EP;Bertelsen MF;Sheldon FH;Brumfield RT;Mello CV;Lovell PV;Wirthlin M;Schneider MP;Prosdocimi F;Samaniego JA;Vargas Velazquez AM;Alfaro-Núñez A;Campos PF;Petersen B;Sicheritz-Ponten T;Pas A;Bailey T;Scofield P;Bunce M;Lambert DM;Zhou Q;Perelman P;Driskell AC;Shapiro B;Xiong Z;Zeng Y;Liu S;Li Z;Liu B;Wu K;Xiao J;Yinqi X;Zheng Q;Zhang Y;Yang H;Wang J;Smeds L;Rheindt FE;Braun M;Fjeldsa J;Orlando L;Barker FK;Jønsson KA;Johnson W;Koepfli KP;O'Brien S;Haussler D;Ryder OA;Rahbek C;Willerslev E;Graves GR;Glenn TC;McCormack J;Burt D;Ellegren H;Alström P;Edwards SV;Stamatakis A;Mindell DP;Cracraft J;Braun EL;Warnow T;Jun W;Gilbert MT;Zhang G
通讯作者：
Zhang G
影响因子：
11.8
作者：
Atit, R;Conlon, R;Niswander, L
通讯作者：
Niswander, L
影响因子：
4.4
作者：
Aslam, Muhammad L.;Bastiaansen, John W. M.;Groenen, Martien A. M.
通讯作者：
Groenen, Martien A. M.