GABA in the medial prefrontal cortex regulates anxiety-like behavior during the postpartum period.
GABA in the medial prefrontal cortex regulates anxiety-like behavior during the postpartum period.
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DOI：
10.1016/j.bbr.2020.112967
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发表时间：
2021-02-01
影响因子：
2.7
通讯作者：
Leuner B
中科院分区：
文献类型：
--
作者：
Sabihi S;Goodpaster C;Maurer S;Leuner B
产后期通常伴随着情绪变化，对许多新妈妈来说，这包括焦虑的减少。先前在啮齿类动物中的研究表明，产后焦虑的减轻依赖于后代的接触，并进一步暗示增强的GABA能神经传递是一种潜在机制。然而，特定的大脑区域，GABA的行为，以调节后代引起的减少产后焦虑需要进一步调查。在这里，我们测试的假设，后代的相互作用抑制焦虑样行为在产后女性通过GABA信号在内侧前额叶皮层（mPFC）。我们的研究结果表明，产后减少焦虑样行为，这种影响被取消的局部注入的GABAA受体拮抗剂荷包牡丹碱在mPFC。我们还表明，激活GABAA受体的mPFC的激动剂蝇蕈醇是有效的恢复anxiolyisis从他们的幼崽分开的母亲。最后，我们发现，在小狗分离的母亲焦虑样行为的增加伴随着较低的数量和百分比的激活GABA能神经元内的mPFC。总之，这些结果表明，母亲与子女的互动减少产后女性的焦虑通过GABAA神经传递的mPFC，并在这样做提供洞察机制，可能成为功能失调的母亲谁经历产后焦虑。
The postpartum period is commonly accompanied by emotional changes, which for many new mothers includes a reduction in anxiety. Previous research in rodents has shown that the postpartum attenuation in anxiety is dependent on offspring contact and has further implicated enhanced GABAergic neurotransmission as an underlying mechanism. However, the specific brain regions where GABA acts to regulate the offspring-induced reduction in postpartum anxiety requires further investigation. Here, we test the hypothesis that offspring interactions suppress anxiety-like behavior in postpartum females via GABA signaling in the medial prefrontal cortex (mPFC). Our results show a postpartum reduction in anxiety-like behavior, an effect which was abolished by localized infusion of the GABAA receptor antagonist bicuculline in the mPFC. We also show that activation of GABAA receptors in the mPFC by the agonist muscimol was effective in restoring anxiolyisis in mothers separated from their pups. Lastly, we show that heightened anxiety-like behavior in pup-separated mothers was accompanied by a lower number and percentage of activated GABAergic neurons within the mPFC. Together, these results suggest that mother-offspring interactions reduce anxiety in postpartum females via GABAA neurotransmission in the mPFC and in doing so provide insight into mechanisms that may become dysfunctional in mothers who experience high postpartum anxiety.
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影响因子：
11
作者：
Canetta S;Bolkan S;Padilla-Coreano N;Song LJ;Sahn R;Harrison NL;Gordon JA;Brown A;Kellendonk C
通讯作者：
Kellendonk C
影响因子：
2.9
作者：
BITRAN, D;HILVERS, RJ;KELLOGG, CK
通讯作者：
KELLOGG, CK
影响因子：
2.8
作者：
Ahmed, Eman I.;Northcutt, Katharine V.;Lonstein, Joseph S.
通讯作者：
Lonstein, Joseph S.
影响因子：
3.1
作者：
Arriaga-Avila, Virginia;Martinez-Abundis, Eduardo;Guevara-Guzman, Rosalinda
通讯作者：
Guevara-Guzman, Rosalinda
影响因子：
3.4
作者：
HANSEN, S;FERREIRA, A;SELART, ME
通讯作者：
SELART, ME