Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles.
Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles.
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DOI：
10.1126/sciadv.abn5315
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发表时间：
2022-07-15
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
下一代疗法需要先进的药物输送平台，能够精确控制形态和释放动力学。最近开发的微加工技术能够制造具有中空核壳结构的新型可注射微粒，该结构显示出脉动释放动力学，从而提供了这种能力。在这里，我们研究了这项技术以及由此产生的核壳微观结构。我们证明，脉冲释放是由聚合物基质孔隙率的突然增加控制的，导致形成连接核心与环境的多孔路径。此外，研究范围内的释放动力学主要与颗粒几何形状无关，但高度依赖于其组成。开发了一种定性技术来研究颗粒中 pH 值演变的模式。计算模型成功地模拟了变形，表明颗粒在释放之前突然膨胀。这项研究的结果有助于理解和设计先进的药物输送系统。这项工作研究了 3D 打印生物材料的功能，与传统生物材料相比，得到了一些意想不到的观察结果。
Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displays pulsatile release kinetics, providing such capabilities. Here, we study this technology and the resulting core-shell microstructures. We demonstrated that pulsatile release is governed by a sudden increase in porosity of the polymeric matrix, leading to the formation of a porous path connecting the core to the environment. Moreover, the release kinetics within the range studied remained primarily independent of the particle geometry but highly dependent on its composition. A qualitative technique was developed to study the pattern of pH evolution in the particles. A computational model successfully modeled deformations, indicating sudden expansion of the particle before onset of release. Results of this study contribute to the understanding and design of advanced drug delivery systems. This work studies how 3D-printed biomaterials function, with some unexpected observations compared to traditional biomaterials.
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影响因子：
9.6
作者：
Estourgie, SH;Nieweg, OE;Kroon, BBR
通讯作者：
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通讯作者：
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通讯作者：
Sarmadi, Morteza
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