The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration.
The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration.
复制标题
LIPC rs493258 多态性与年龄相关性黄斑变性易感性之间的关联。
DOI：
10.3390/ijerph13101022
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发表时间：
2016-10-18
影响因子：
--
通讯作者：
Ma L
中科院分区：
文献类型：
--
作者：
Wang Y;Wang M;Zhang X;Nie J;Zhang M;Liu X;Ma L
本研究的目的是评估肝脂肪酶 (LIPC) rs493258 多态性与年龄相关性黄斑变性 (AMD) 易感性之间的关系。我们在 PubMed、EMBASE 和 ISI 科学数据库网络中进行了系统检索，以识别截至 2016 年 4 月无语言限制的合格已发表研究。使用荟萃分析方法在不同遗传模型下估计了 AMD 不同阶段的合并比值比 (OR) 和 95% 置信区间 (CI)。包含 20,559 例病例和 17,200 例对照的七项研究符合纳入标准并被纳入荟萃分析。在等位基因模型下，LIPC rs493258 多态性与较低的 AMD 风险显着相关（OR = 0.87，95% CI = 0.84–0.90）。在其他遗传模型中也观察到该变异与 AMD 之间的显着关系（OR 范围为 0.71 至 0.86，所有 p < 0.05）。基于种族的分层分析发现，LIPC rs493258 多态性与高加索人群中疾病风险降低显着相关，但在亚洲人群中则不然。对于晚期 AMD，在等位基因遗传模型中也观察到 rs493258 多态性与该疾病风险较低的显着关联（OR = 0.87，95% CI = 0.83–0.90）。这项荟萃分析表明，LIPC rs493258 多态性中的 T 等位基因与任何和晚期 AMD 的风险显着相关。该位点与不同人群中早期和晚期 AMD 风险的关联需要进一步探索。
The purpose of this study was to evaluate the association of the hepatic lipase (LIPC) rs493258 polymorphism and susceptibility to age-related macular degeneration (AMD). A systematic search in PubMed, EMBASE, and ISI web of science databases was performed to identify eligible published studies without language restrictions up to April 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) in different stages of AMD were estimated under different genetic models using meta-analytic methods. Seven studies comprising 20,559 cases and 17,200 controls met the inclusion criteria and were included in the meta-analysis. The LIPC rs493258 polymorphism showed a significant association with a lower risk of AMD under the allelic model (OR = 0.87, 95% CI = 0.84–0.90). Significant relationships between the variant and AMD were also observed in other genetic models (OR ranging from 0.71 to 0.86, all p < 0.05). Stratified analysis based on ethnicity found that LIPC rs493258 polymorphism had a significant association with the decreased risk of the disease in the Caucasian population, but not in the Asian population. For late AMD, significant associations of the rs493258 polymorphism with a lower risk of this disease were also observed in the allelic genetic model (OR = 0.87, 95% CI = 0.83–0.90). This meta-analysis demonstrates that the T allele in the LIPC rs493258 polymorphism was significantly associated with the risk of any and late AMD. The associations of the locus with early and late AMD risk in various populations need further exploration.
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影响因子：
3.5
作者：
Cipriani, Valentina;Leung, Hin-Tak;Yates, John R. W.
通讯作者：
Yates, John R. W.
影响因子：
3.7
作者：
Merle BM;Maubaret C;Korobelnik JF;Delyfer MN;Rougier MB;Lambert JC;Amouyel P;Malet F;Le Goff M;Dartigues JF;Barberger-Gateau P;Delcourt C
通讯作者：
Delcourt C
影响因子：
4.4
作者：
Huang, Jiahn-Dar;Curcio, Christine A.;Johnson, Mark
通讯作者：
Johnson, Mark
影响因子：
4.6
作者：
Indaram M;Ma W;Zhao L;Fariss RN;Rodriguez IR;Wong WT
通讯作者：
Wong WT
DOI：
10.1155/2011/274629
发表时间：
2011
期刊：
Cholesterol
影响因子：
--
作者：
G HB;Rao VS;Kakkar VV
通讯作者：
Kakkar VV