Exercise-induced 'browning' of adipose tissues.
Exercise-induced 'browning' of adipose tissues.
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DOI：
10.1016/j.metabol.2017.11.009
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Symonds ME
中科院分区：
文献类型：
--
作者：
Aldiss P;Betts J;Sale C;Pope M;Budge H;Symonds ME
全球肥胖率继续上升，这必然是能量摄入和能量消耗长期失衡的结果。这是由于现有脂肪细胞肥大和脂肪细胞前体增生导致脂肪组织扩张的结果。运动对脂肪组织有许多生理益处，这可能有助于相关的心脏代谢益处。最近已经证明，运动通过一系列机制诱导脂肪组织中从能量储存白色脂肪细胞到产热米色脂肪细胞的表型转换。这就产生了一种假设，即脂肪细胞“布朗宁”的过程可能是体力活动人群心脏代谢健康改善的部分基础。有趣的是，“布朗宁”也发生在对各种压力的反应中，可能代表了一种适应性反应。在运动的背景下，尚不清楚米色脂肪细胞的出现是否对代谢有益，或者它们是否作为对运动诱导的应激的短暂适应过程而发生。本文综述了运动诱导的“布朗宁”过程可能发生的各种机制（如运动过程中脂肪酸氧化、隔热能力降低、应激源和血管生成）。运动诱导布朗宁的机制。在正文中详细讨论。
Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy of existing adipocytes and hyperplasia of adipocyte pre-cursors. Exercise elicits numerous physiological benefits on adipose tissue, which are likely to contribute to the associated cardiometabolic benefits. More recently it has been demonstrated that exercise, through a range of mechanisms, induces a phenotypic switch in adipose tissue from energy storing white adipocytes to thermogenic beige adipocytes. This has generated the hypothesis that the process of adipocyte ‘browning’ may partially underlie the improved cardiometabolic health in physically active populations. Interestingly, ‘browning’ also occurs in response to various stressors and could represent an adaptive response. In the context of exercise, it is not clear whether the appearance of beige adipocytes is metabolically beneficial or whether they occur as a transient adaptive process to exercise-induced stresses. The present review discusses the various mechanisms (e.g. fatty acid oxidation during exercise, decreased thermal insulation, stressors and angiogenesis) by which the exercise-induced ‘browning’ process may occur. Mechanisms of exercise-induced browning. Discussed in detail in-text.
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影响因子：
20.1
作者：
Antonopoulos AS;Margaritis M;Verheule S;Recalde A;Sanna F;Herdman L;Psarros C;Nasrallah H;Coutinho P;Akoumianakis I;Brewer AC;Sayeed R;Krasopoulos G;Petrou M;Tarun A;Tousoulis D;Shah AM;Casadei B;Channon KM;Antoniades C
通讯作者：
Antoniades C
DOI：
10.1016/j.numecd.2012.01.013
发表时间：
2013-06-01
影响因子：
3.9
作者：
De Matteis, R.;Lucertini, F.;Cuppini, R.
通讯作者：
Cuppini, R.
影响因子：
16.6
作者：
Berry DC;Jiang Y;Graff JM
通讯作者：
Graff JM
影响因子：
9.8
作者：
DESPRES, JP;BOUCHARD, C;THERIAULT, G
通讯作者：
THERIAULT, G
影响因子：
9.8
作者：
Disanzo, Beth L.;You, Tongjian
通讯作者：
You, Tongjian