White matter structural differences in young children with type 1 diabetes: a diffusion tensor imaging study.
White matter structural differences in young children with type 1 diabetes: a diffusion tensor imaging study.
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DOI：
10.2337/dc12-0017
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发表时间：
2012-11
期刊：
影响因子：
16.2
通讯作者：
Buckingham BA
中科院分区：
文献类型：
--
作者：
Aye T;Barnea-Goraly N;Ambler C;Hoang S;Schleifer K;Park Y;Drobny J;Wilson DM;Reiss AL;Buckingham BA
探讨1型糖尿病儿童认知能力与白色组织微结构改变的临床相关性。年龄3至<10岁的1型糖尿病儿童（n = 22）和年龄和性别匹配的健康对照组（n = 14）完成了神经认知测试和DTI扫描。与健康对照组相比，1型糖尿病儿童颞叶和顶叶区域的轴向扩散率（AD）值较低（P = 0.046）。组间各向异性分数和径向扩散率（RD）无显著差异。在糖尿病组中，时间加权HbA1c与RD之间存在显著的正相关性（P = 0.028）。较高的时间加权HbA1c值与通过全量表智商测量的较低的整体智力功能显著相关（P = 0.03）。与对照组相比，1型糖尿病儿童有显着不同的WM结构（AD测量）。此外，WM结构差异（通过RD测量）与HbA1c值显著相关。需要进一步的研究来确定1型糖尿病幼儿的WM微结构差异是否能预测未来的神经认知结果。
To detect clinical correlates of cognitive abilities and white matter (WM) microstructural changes using diffusion tensor imaging (DTI) in young children with type 1 diabetes. Children, ages 3 to <10 years, with type 1 diabetes (n = 22) and age- and sex-matched healthy control subjects (n = 14) completed neurocognitive testing and DTI scans. Compared with healthy controls, children with type 1 diabetes had lower axial diffusivity (AD) values (P = 0.046) in the temporal and parietal lobe regions. There were no significant differences between groups in fractional anisotropy and radial diffusivity (RD). Within the diabetes group, there was a significant, positive correlation between time-weighted HbA1c and RD (P = 0.028). A higher, time-weighted HbA1c value was significantly correlated with lower overall intellectual functioning measured by the full-scale intelligence quotient (P = 0.03). Children with type 1 diabetes had significantly different WM structure (as measured by AD) when compared with controls. In addition, WM structural differences (as measured by RD) were significantly correlated with their HbA1c values. Additional studies are needed to determine if WM microstructural differences in young children with type 1 diabetes predict future neurocognitive outcome.
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