Comparison of genomic and amino acid sequences of eight Japanese encephalitis virus isolates from bats.

Comparison of genomic and amino acid sequences of eight Japanese encephalitis virus isolates from bats.
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DOI:
10.1007/s00705-013-1777-5
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发表时间:
2013-12
影响因子:
2.7
通讯作者:
Chen Q
Chen Q
中科院分区:
医学4区
文献类型:
--
作者:
Liu S;Li X;Chen Z;Chen Y;Zhang Q;Liao Y;Zhou J;Ke X;Ma L;Xiao J;Wu Y;Chen Z;Zhou J;Zheng X;Li J;Chen Q

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我们比较了源自中国蝙蝠的八种日本脑炎病毒(JEV)分离株的核苷酸序列并推导了氨基酸序列。我们还将蝙蝠乙脑病毒分离株与 GenBank 中提供的其他乙脑病毒分离株进行了比较,以确定它们的遗传相似性。我们发现在不同地理区域、不同时间段从不同蝙蝠物种中分离出的蝙蝠 JEV 具有高度的遗传同质性。所有八株蝙蝠乙脑病毒分离株均属于基因型 III。蝙蝠乙脑病毒分离株的平均进化率低于其他来源的分离株,但这种差异不具有统计学意义。根据这些结果,我们推测蝙蝠乙脑病毒分离株可能在进化上是保守的。 8 株蝙蝠乙脑病毒分离株在系统发育上与蚊子 BN19 和人李玉杰分离株的乙脑病毒相似。这些结果表明蝙蝠可能参与了乙脑病毒的自然循环。
We compared nucleotide and deduced amino acid sequences of eight Japanese encephalitis virus (JEV) isolates derived from bats in China. We also compared the bat JEV isolates with other JEV isolates available from GenBank to determine their genetic similarity. We found a high genetic homogeneity among the bat JEVs isolated in different geographical areas from various bat species at different time periods. All eight bat JEV isolates belonged to genotype III. The mean evolutionary rate of bat JEV isolates was lower than those of isolates of other origin, but this difference was not statistically significant. Based on these results, we presume that the bat JEV isolates might be evolutionarily conserved. The eight bat JEV isolates were phylogenetically similar to mosquito BN19 and human Liyujie isolates of JEV. These results indicate that bats might be involved in natural cycle of JEV.
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发表时间: 1999-01-01
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