Endothelial progenitor cells: identity defined?
Endothelial progenitor cells: identity defined?
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DOI：
10.1111/j.1582-4934.2008.00598.x
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发表时间：
2009-01
影响因子：
5.3
通讯作者：
Case J
中科院分区：
文献类型：
--
作者：
Timmermans F;Plum J;Yöder MC;Ingram DA;Vandekerckhove B;Case J
在过去的十年中，研究人员已经获得了重要的见解骨髓（BM）来源的细胞在成人新血管形成的作用。BM衍生细胞的一个子集，称为内皮祖细胞（EPC），一直是特别感兴趣的，因为这些细胞被认为是新血管形成和新内皮化的位点，并原位分化为内皮细胞（EC），这一过程称为出生后血管发生。因此，EPCs被认为是治疗人类血管疾病的潜在再生工具，也是肿瘤病理学中限制血管生长的可能靶点。然而，相互矛盾的结果已经在该领域的报告，和EPCs的识别，表征，和确切的作用，在血管生物学仍然是一个备受争议的主题。本综述的重点是EPCs领域的争议问题，这些问题与缺乏独特的EPC标记物、与循环中EPCs缺乏相关的识别挑战以及EPCs、造血细胞和成熟EC之间重要的表型和功能重叠有关。我们还讨论了我们最近的研究结果的起源内皮生长细胞（EOCs），表明这种在体外定义的EC人口不源自循环的CD 133+细胞或CD 45+造血细胞。
In the past decade, researchers have gained important insights on the role of bone marrow (BM)-derived cells in adult neovascularization. A subset of BM-derived cells, called endothelial progenitor cells (EPCs), has been of particular interest, as these cells were suggested to home to sites of neovascularization and neoendothelialization and differentiate into endothelial cells (ECs) in situ, a process referred to as postnatal vasculogenesis. Therefore, EPCs were proposed as a potential regenerative tool for treating human vascular disease and a possible target to restrict vessel growth in tumour pathology. However, conflicting results have been reported in the field, and the identification, characterization, and exact role of EPCs in vascular biology is still a subject of much discussion. The focus of this review is on the controversial issues in the field of EPCs which are related to the lack of a unique EPC marker, identification challenges related to the paucity of EPCs in the circulation, and the important phenotypical and functional overlap between EPCs, haematopoietic cells and mature ECs. We also discuss our recent findings on the origin of endothelial outgrowth cells (EOCs), showing that this in vitro defined EC population does not originate from circulating CD133+ cells or CD45+ haematopoietic cells.
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