Association of Epstein-Barr virus infection with peripheral immune parameters and clinical outcome in advanced nasopharyngeal carcinoma.
Association of Epstein-Barr virus infection with peripheral immune parameters and clinical outcome in advanced nasopharyngeal carcinoma.
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晚期鼻咽癌中 Epstein-Barr 病毒感染与外周免疫参数及临床结果的关系
DOI：
10.1038/s41598-020-78892-0
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发表时间：
2020-12-15
影响因子：
4.6
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Tao D;Zhang N;Huang Q;Ge C;Li Q;Li S;Weng K;Guo Q;Sui J;Wang C;Zhang X;Wang Y
本研究旨在探讨EB病毒（EBV）与晚期鼻咽癌（NPC）患者外周血免疫细胞计数及临床预后的关系。在一项回顾性设计中，146例IV期NPC患者入选本研究。我们确定了晚期NPC患者EBV状态与外周血免疫细胞计数、远处转移和长期生存的关系。所有患者中有87例（59.6%）EBV阳性。与NK细胞计数正常的患者相比，NK细胞计数较低的患者EBV病毒载量显著降低（中位数：614.0 vs.2190.0 copies/mL，P= 0.024）。EBV阳性患者肝转移发生率明显高于EBV阴性患者（32.6%vs.23.7%，P = 0.021）。多因素回归分析显示EBV感染与肝转移独立相关（OR：2.33，P = 0.043）。EBV阳性患者的PFS（P= 0.001）和OS（P= 0.001）明显低于EBV阴性患者。多因素考克斯回归分析显示，EBV感染与晚期鼻咽癌患者的PFS（HR：1.94，P = 0.003）和OS（HR：2.12，P = 0.014）显著相关。总之，EBV感染与肝转移的高风险相关，也是晚期NPC患者PFS和OS的独立阴性预测因子。EBV感染与较低的CD8%和较高的NK%相关，而较低的NK细胞计数与较低的EBV病毒载量相关。
The purpose of this study was to investigate the association of Epstein-Barr virus (EBV) with peripheral blood immune cell counts and clinical outcomes in advanced nasopharyngeal carcinoma (NPC) patients. In a retrospective design, 146 patients with NPC at stage IV were enrolled in this study. The association of EBV status with peripheral blood immune cell counts, distant metastases, and long-term survival in patients with advanced NPC were determined. Eighty-seven (59.6%) of all patients were positive for EBV. Compared with patients with normal NK cell count, patients with lower NK cell count showed a significantly lower EBV viral load (median: 614.0vs.2190.0 copies/mL,P= 0.024). EBV-positive patients showed a significantly higher incidence of liver metastasis than EBV-negative patients (32.6% vs. 23.7%,P= 0.021). Multi-variant regression analysis showed that EBV infection was independently associated with liver metastasis (OR: 2.33,P= 0.043). EBV positive patients showed a significantly worse PFS (P= 0.001) and OS (P= 0.001) than EBV negative patients. Multivariate Cox regression analysis revealed that EBV infection was independently associated with a worse PFS (HR: 1.94,P= 0.003), and OS (HR: 2.12,P= 0.014) in advanced NPC. In conclusion, EBV infection is associated with a high risk of liver metastasis and is also an independent negative predictor for PFS and OS in patients with advanced NPC. EBV infection is associated with lower CD8% and higher NK%, while lower NK cell count is associated with lower EBV viral load.
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影响因子：
1.8
作者：
Lei, L.;Mao, Y.;Wang, Y.
通讯作者：
Wang, Y.
影响因子：
64.8
作者：
LI, QX;YOUNG, LS;RICKINSON, AB
通讯作者：
RICKINSON, AB
影响因子：
4.3
作者：
Qiu, Hai-Bo;Zhang, Li-Yi;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
6.2
作者：
Shao, JY;Li, YH;Zeng, YX
通讯作者：
Zeng, YX
影响因子：
--
作者：
Wang HM;Lin TL;Kuo YC;Li HP;Chang KP;Lin CY;Fan HC;Lin AC;Hsieh CH;Tsang NM;Lee LY;Chan SC;Lui KW;Chang YS;Hsu CL
通讯作者：
Hsu CL