Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.
Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.
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DOI：
10.1126/scisignal.2000634
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发表时间：
2010-02-23
影响因子：
7.3
通讯作者：
Li CY
中科院分区：
文献类型：
--
作者：
Li F;Huang Q;Chen J;Peng Y;Roop DR;Bedford JS;Li CY
再生受损组织的能力是多细胞生物的共同特征。我们报道了凋亡性细胞死亡在促进小鼠伤口愈合和组织再生中的作用。凋亡细胞释放生长信号，刺激祖细胞或干细胞的增殖。这一过程中的关键参与者是半胱天冬酶3和7，这是在细胞凋亡的执行阶段激活的蛋白酶，有助于细胞死亡。缺乏这两种半胱天冬酶的小鼠在皮肤伤口愈合和肝再生方面都有缺陷。前列腺素E2是干细胞或祖细胞增殖和组织再生的启动子，作用于半胱天冬酶的下游。我们建议将凋亡细胞中的执行者半胱天冬酶促进多细胞生物中伤口愈合和组织再生的途径称为“凤凰崛起”途径。
The ability to regenerate damaged tissues is a common characteristic of multicellular organisms. We report a role for apoptotic cell death in promoting wound healing and tissue regeneration in mice. Apoptotic cells released growth signals that stimulated the proliferation of progenitor or stem cells. Key players in this process were caspases 3 and 7, proteases activated during the execution phase of apoptosis that contribute to cell death. Mice lacking either of these caspases were deficient in skin wound healing and in liver regeneration. Prostaglandin E2, a promoter of stem or progenitor cell proliferation and tissue regeneration, acted downstream of the caspases. We propose to call the pathway by which executioner caspases in apoptotic cells promote wound healing and tissue regeneration in multicellular organisms the “Phoenix Rising” pathway.
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影响因子：
64.5
作者：
Goessling W;North TE;Loewer S;Lord AM;Lee S;Stoick-Cooper CL;Weidinger G;Puder M;Daley GQ;Moon RT;Zon LI
通讯作者：
Zon LI
影响因子：
64.8
作者：
FEHER, I;GIDALI, J
通讯作者：
GIDALI, J
影响因子：
3.4
作者：
HANSON, WR;THOMAS, C
通讯作者：
THOMAS, C
DOI：
10.1098/rstb.2004.1464
发表时间：
2004-05-29
影响因子：
6.3
作者：
Braun, S;Keller, UAD;Werner, S
通讯作者：
Werner, S
影响因子：
4.8
作者：
Atsumi, G;Tajima, M;Kudo, I
通讯作者：
Kudo, I