Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.
Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.
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DOI：
10.1080/02656736.2021.1905189
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发表时间：
2021
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--
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中科院分区：
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组织摧毁术是第一种由实时成像引导的非侵入性、非电离和非热消融技术。使用从体外传递的聚焦超声，组织摧毁术通过空化机械地破坏组织，使目标变成无细胞碎片。组织摧毁消融区的材料在1-2个月内被身体吸收，留下最小的残余疤痕。在动物模型中，组织破坏术也被证明可以刺激免疫反应并诱导远位效应，这可能对未来的癌症治疗具有积极意义。在临床前研究中，组织摧毁术已被广泛应用，包括治疗癌症、神经系统疾病和心血管疾病。已经进行了三项使用组织碎石术治疗良性前列腺增生、肝癌和钙化瓣膜狭窄的人体临床试验。本文综述了组织摧毁术的起源、机制、生物效应、参数、仪器以及临床前和人体研究的最新结果。
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris. The material in the histotripsy ablation zone is absorbed by the body within 1–2 months, leaving a minimal remnant scar. Histotripsy has also been shown to stimulate an immune response and induce abscopal effects in animal models, which may have positive implications for future cancer treatment. Histotripsy has been investigated for a wide range of applications in preclinical studies, including the treatment of cancer, neurological diseases, and cardiovascular diseases. Three human clinical trials have been undertaken using histotripsy for the treatment of benign prostatic hyperplasia, liver cancer, and calcified valve stenosis. This review provides a comprehensive overview of histotripsy covering the origin, mechanism, bioeffects, parameters, instruments, and the latest results on preclinical and human studies.
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