The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent.
The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent.
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DOI：
10.1038/npp.2008.154
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发表时间：
2009-05
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影响因子：
--
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中科院分区：
文献类型：
--
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社会关系显著影响生理和行为，包括下丘脑-垂体-肾上腺轴，焦虑和心理健康。由于分离或死亡而造成的社会关系的破坏往往会导致深刻的悲伤，抑郁和身体疾病。由于一夫一妻制的草原田鼠与交配伴侣形成持久的、选择性的配对关系，它们提供了一种动物模型来研究配对关系的生理后果，从而研究失去结合伴侣的情况。雄性草原田鼠与一个新的雌性或雄性兄弟姐妹配对。5天后，每组中一半的雄性与伴侣分开。高架十字迷宫、强迫游泳和悬尾试验用于评估焦虑样和被动压力应对行为，这些行为表明抑郁样行为。4天后，从女性而不是男性伴侣分离，实验男性表现出增加被动的压力应对。这种影响被废除的长期脑室内输注的非选择性促肾上腺皮质激素释放因子（CRF）受体拮抗剂，而不破坏债券本身。CRF 1型和2型受体均参与被动应激应对行为的出现。此外，与女性配对与终纹床核中CRF mRNA升高相关，伴侣丢失引起循环皮质类固醇和肾上腺重量显著增加。我们推测，CRF系统可能介导的厌恶性影响后，从女性合作伙伴，这可能有助于接近寻求配对绑定的个人之间的分离。因此，草原田鼠模型可以提供深入了解大脑机制参与的精神病理后果的合作伙伴损失。
Social relationships significantly influence physiology and behavior, including the hypothalamo–pituitary–adrenal axis, anxiety, and mental health. Disruption of social bonds through separation or death often results in profound grieving, depression, and physical illness. As the monogamous prairie vole forms enduring, selective pair bonds with the mating partner, they provide an animal model to study the physiological consequences of pair bonding and, thus, the loss of the bonded partner. Male prairie voles were paired with a novel female or male sibling. After 5 days, half of the males of each group were separated from the partner. Elevated plus-maze, forced swim, and tail suspension tests were used to assess anxiety-like and passive stress-coping behaviors indicative of depressive-like behavior. Following 4 days of separation from the female but not the male partner, experimental males displayed increased passive stress-coping. This effect was abolished by long-term intracerebroventricular infusion of a nonselective corticotropin-releasing factor (CRF) receptor antagonist without disrupting the bond itself. Both CRF type 1 and 2 receptors were involved in the emergence of passive stress-coping behavior. Furthermore, pairing with a female was associated with elevated CRF mRNA in the bed nucleus of the stria terminalis, and partner loss elicited a pronounced increase in circulating corticosteroid and adrenal weight. We speculate that the CRF system may mediate an aversive affect following separation from the female partner, which may facilitate proximity seeking between the pair-bonded individuals. Hence, the prairie vole model may provide insights into brain mechanisms involved in the psychopathological consequences of partner loss.
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影响因子：
3.5
作者：
Bale, TL
通讯作者：
Bale, TL
影响因子：
3
作者：
CARTER, CS;GETZ, LL
通讯作者：
GETZ, LL
影响因子：
2.9
作者：
DeVries, AC;Glasper, ER;Detillion, CE
通讯作者：
Detillion, CE
DOI：
10.1073/pnas.93.21.11980
发表时间：
1996-10-15
影响因子：
11.1
作者：
DeVries, AC;DeVries, MB;Carter, CS
通讯作者：
Carter, CS
影响因子：
5.3
作者：
Aragona, BJ;Liu, Y;Wang, ZX
通讯作者：
Wang, ZX