Incidence of herpes zoster ophthalmicus: results from the Pacific Ocular Inflammation Study.
Incidence of herpes zoster ophthalmicus: results from the Pacific Ocular Inflammation Study.
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DOI：
10.1016/j.ophtha.2012.09.007
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发表时间：
2013-03
期刊：
影响因子：
13.7
通讯作者：
Acharya NR
中科院分区：
文献类型：
--
作者：
Borkar DS;Tham VM;Esterberg E;Ray KJ;Vinoya AC;Parker JV;Uchida A;Acharya NR
通过种族、性别和年龄组的比较，提供基于人群的带状疱疹眼（HZO）发病率估计值，并估计带状疱疹后神经痛（PHN）的频率。回顾性、基于人群的队列研究期间入组Kaiser Permanente夏威夷健康计划的所有患者（N= 217，061）。查询Kaiser Permanente夏威夷电子病历中2006年1月1日至2007年12月31日期间的所有患者就诊情况，以获得与HZO对应的国际疾病分类第9版（ICD 9）代码。审查图表以确认HZO的诊断并收集有关特定眼部表现的信息。以电子方式收集PHN的人口统计学数据和信息。计算整个人群以及年龄、性别和种族特异性亚组的每100，000人-年的发病率。研究期间HZO的临床诊断。在这217，061人的人群中确定了134例HZO病例。总发生率为30.9/100，000人-年（95%置信区间（CI）：25.9-36.6）。65岁及以上人群的发病率为104.6/100，000人-年（95% CI：79.0-135.9），约为其余人群的5倍（p<0.001）。HZO最常见的临床表现是皮炎，其次是角膜炎和结膜炎。太平洋岛民的HZO发生率为19.0/100，000人-年（95% CI：12.4- 28.3），显著低于非太平洋岛民（p=0.007）。21%的HZO患者发生PHN。年龄较大和HZO伴角膜炎、结膜炎和/或葡萄膜炎是PHN的危险因素。这项研究提供了一个基于人口的HZO估计，并强调了不同年龄和种族群体的差异。它还表明，人口特征可能有助于确定发展HZO的风险。
To provide a population-based estimate of the incidence of herpes zoster ophthalmicus (HZO) with comparisons across racial, gender, and age groups, as well as to estimate the frequency of postherpetic neuralgia (PHN). Retrospective, population-based cohort study All patients enrolled in the Kaiser Permanente Hawaii health plan during the study period (N=217,061). All patient encounters between January 1, 2006 and December 31, 2007 in the electronic medical record of Kaiser Permanente Hawaii were queried for International Classification of Diseases, 9th Edition (ICD9) codes corresponding to HZO. Charts were reviewed to confirm a diagnosis of HZO and to collect information on specific ocular manifestations. Demographic data and information on PHN were collected electronically. Incidence rates were calculated per 100,000 person-years for the entire population, as well as for age-, gender-, and race-specific subgroups. Clinical diagnosis of HZO during the study period. One hundred thirty-four cases of HZO were identified in this population of 217,061 people. The overall incidence was 30.9 per 100,000 person-years (95% confidence interval (CI): 25.9–36.6). The incidence rate for the population 65 years of age and over was 104.6 per 100,000 person-years (95% CI: 79.0–135.9), approximately five times the remainder of the population (p<0.001). The most common manifestation of HZO was dermatitis, followed by keratitis and conjunctivitis. The incidence of HZO for Pacific Islanders was 19.0 per 100,000 person-years (95% CI: 12.4– 28.3), which was significantly lower than the rate for non-Pacific Islanders (p=0.007). Twenty-one percent of HZO patients developed PHN. Older age and HZO with keratitis, conjunctivitis, and/or uveitis were found to be risk factors for PHN. This study provides a population-based estimate of HZO and highlights differences across various age and racial groups. It also suggests that demographic characteristics may be useful in determining the risk of developing HZO.
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影响因子：
1.6
作者：
RAGOZZINO, MW;MELTON, LJ;PERRY, HO
通讯作者：
PERRY, HO
影响因子：
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作者：
DONAHUE, JG;CHOO, PW;PLATT, R
通讯作者：
PLATT, R
影响因子：
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作者：
Galil, K;Choo, PW;Platt, R
通讯作者：
Platt, R
影响因子：
11.2
作者：
ELLIOTT, KJ
通讯作者：
ELLIOTT, KJ
影响因子：
5.5
作者：
Chapman, RS;Cross, KW;Fleming, DM
通讯作者：
Fleming, DM