Caenorhabditis elegans learning in a structured maze is a multisensory behavior.
Caenorhabditis elegans learning in a structured maze is a multisensory behavior.
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DOI：
10.1016/j.isci.2021.102284
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发表时间：
2021-04-23
期刊：
影响因子：
5.8
通讯作者：
Hsu AL
中科院分区：
文献类型：
--
作者：
Gourgou E;Adiga K;Goettemoeller A;Chen C;Hsu AL
我们表明，秀丽隐杆线虫学会将食物与本体感受线索和周围环境（迷宫）结构信息相结合，通过机械感觉感知。通过使用定制的蠕虫迷宫平台，我们证明，秀丽隐杆线虫年轻的成年人可以在T形迷宫中找到食物，并根据这种经验，学会到达特定的迷宫臂。秀丽隐杆线虫在迷宫内学习是可能的，它类似于工作记忆，它战胜了冲突的环境线索。我们提供的证据表明，所观察到的学习是一个食物触发的多感官行为，这需要机械感觉和本体感觉输入，并利用线索的结构特征线虫的环境和他们的身体动作。CREB样转录因子和多巴胺信号也参与迷宫的表现。最后，我们表明，所观察到的衰老驱动的秀丽隐杆线虫在迷宫中的学习能力下降可以通过饥饿来逆转。秀丽隐杆线虫可以被训练在T形迷宫中到达目标手臂学习需要触觉和本体感受线索的贡献秀丽隐杆线虫在迷宫环境中遵循一种反应学习策略学习是短期的，对分心敏感行为神经科学;生物科学;神经科学
We show that C. elegans nematodes learn to associate food with a combination of proprioceptive cues and information on the structure of their surroundings (maze), perceived through mechanosensation. By using the custom-made Worm-Maze platform, we demonstrate that C. elegans young adults can locate food in T-shaped mazes and, following that experience, learn to reach a specific maze arm. C. elegans learning inside the maze is possible after a single training session, it resembles working memory, and it prevails over conflicting environmental cues. We provide evidence that the observed learning is a food-triggered multisensory behavior, which requires mechanosensory and proprioceptive input, and utilizes cues about the structural features of nematodes' environment and their body actions. The CREB-like transcription factor and dopamine signaling are also involved in maze performance. Lastly, we show that the observed aging-driven decline of C. elegans learning ability in the maze can be reversed by starvation. C. elegans can be trained to reach a target arm in a T-shaped maze Learning requires the contribution of tactile and proprioceptive cues C. elegans follow a kind of response learning strategy in the maze environment Learning is short-term and sensitive to distraction Behavioral Neuroscience; Biological Sciences; Neuroscience
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影响因子：
1.9
作者：
Bardgett, Mark E.;Depenbrock, Melissa;Downs, Nathan;Points, Megan;Green, Leonard
通讯作者：
Green, Leonard
影响因子：
7.8
作者：
Kaeberlein, Tammi L.;Smith, Erica D.;Kaeberlein, Matt
通讯作者：
Kaeberlein, Matt
DOI：
10.1037/0096-1523.29.2.310
发表时间：
2003-04-01
影响因子：
2.1
作者：
Klatzky, RL;Lederman, SJ
通讯作者：
Lederman, SJ
影响因子：
8.2
作者：
Klatzky, RL;Loomis, JM;Golledge, RG
通讯作者：
Golledge, RG
DOI：
10.1895/wormbook.1.137.1
发表时间：
2008-01-24
期刊：
WormBook : the online review of C. elegans biology
影响因子：
--
作者：
Collins, James J;Huang, Cheng;Kornfeld, Kerry
通讯作者：
Kornfeld, Kerry