Effects of plant-derived isoquinoline alkaloids on growth performance and intestinal function of broiler chickens under heat stress.
Effects of plant-derived isoquinoline alkaloids on growth performance and intestinal function of broiler chickens under heat stress.
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在热应激下，植物来源的异喹啉生物碱对肉鸡鸡的生长性能和肠功能的影响。
DOI：
10.1016/j.psj.2020.11.050
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发表时间：
2021-03
期刊：
影响因子：
4.4
通讯作者：
Toyomizu M
中科院分区：
文献类型：
--
作者：
Kikusato M;Xue G;Pastor A;Niewold TA;Toyomizu M
在热应激(HS)条件下饲养的肉鸡生长性能下降，并表现出代谢和免疫学变化。本研究旨在评估添加植物来源的异喹啉生物碱(IQ)的标准化混合物对HS处理的雏鸡的生长性能、蛋白质分解代谢、肠道屏障功能和炎症状态的影响。将360只30日龄罗斯308公鸡随机分为2组：对照组(不添加任何添加剂)和添加100ppm智商的日粮。14日龄时，每组又分成2组，每组分别在22.4℃和33.0℃恒温条件下饲养至42天。每组由6个重复组成，每个重复15只鸡，并为鸡提供随意的水和饲料。在第15~21天，HS组的增重(BWG)和采食量(FI)显著低于TN组(P<0.05)，饲料转化率显著高于TN组(P<0.05)；补充IQ并不能缓解这些因素。在第22-42天，服用智商的HS鸡的最终体重、体重和FI比没有服用的要好(P<0.05)。HS处理增加了血浆过氧化脂质、皮质酮和尿酸浓度以及血清荧光素异硫氰酸酯-葡聚糖(肠屏障功能的标志)，降低了血浆总蛋白含量(P<0.05)。在IQ组中没有观察到这些变化，这表明IQ补充改善了HS下鸡的氧化损伤、蛋白质分解代谢和肠道屏障功能。补充异喹啉生物碱可抑制HS大鼠肠道炎症因子、IL-6、肿瘤坏死因子样因子1A和诱导型一氧化氮合酶的表达(P<0.05)。这些结果表明，添加IQ可以改善HS条件下肉鸡的生长性能，这可能与改善氧化损伤、蛋白质分解代谢、肠道屏障功能和炎症有关。
Broiler chickens reared under heat stress (HS) conditions have decreased growth performance and show metabolic and immunologic alterations. This study aimed to evaluate the effect of supplementation with a standardized blend of plant-derived isoquinoline alkaloids (IQ) on the growth performance, protein catabolism, intestinal barrier function, and inflammatory status of HS-treated chickens. Three hundred sixty 0-day-old Ross 308 male broiler chickens were randomly distributed into 2 treatment groups: control diet (no additives) or diet supplemented with 100 ppm IQ. At day 14, the chicks in each diet group were further divided into 2 groups, each of which was reared under thermoneutral (TN) (22.4°C) or constant HS (33.0°C) conditions until day 42. Each group consisted of 6 replicates with 15 birds per replicate, and chickens were provided ad libitum access to water and feed. During days 15–21, the body weight gain (BWG) and feed intake (FI) were significantly lower in the HS treatment group than in the TN group, and feed conversion ratio was higher (P < 0.05); these factors were not alleviated by IQ supplementation. During days 22–42, the final BW, BWG, and FI of the HS birds were better among those administered IQ than those that were not (P < 0.05). HS treatment increased plasma lipid peroxide, corticosterone, and uric acid concentrations as well as serum fluorescein isothiocyanate–dextran, a marker of intestinal barrier function, and decreased plasma total protein content (P < 0.05). These changes were not observed in the IQ group, suggesting that IQ supplementation improved oxidative damage, protein catabolism, and intestinal barrier function of chickens under HS. Isoquinoline alkaloid supplementation inhibited the expression of intestinal inflammatory factors, IL-6, tumor necrosis factor–like factor 1A, and inducible nitric oxide synthase under HS treatment (P < 0.05). These results suggest that IQ supplementation can improve the growth performance of broiler chickens under HS conditions, which may be associated with amelioration of oxidative damage, protein catabolism, intestinal barrier function, and inflammation.
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影响因子：
2.7
作者：
Liu, H. W.;Li, K.;Deng, W.
通讯作者：
Deng, W.
影响因子：
4.4
作者：
Cramer, T. A.;Kim, H. W.;Kim, Y. H. B.
通讯作者：
Kim, Y. H. B.
DOI：
10.5713/ajas.17.0657
发表时间：
2018-05
期刊：
Asian-Australasian journal of animal sciences
影响因子：
--
作者：
Huang CM;Lee TT
通讯作者：
Lee TT
DOI：
10.1016/j.cbpc.2004.09.013
发表时间：
2004-12-01
影响因子：
2.2
作者：
Lin, H;Decuypere, E;Buyse, J
通讯作者：
Buyse, J
影响因子：
2.4
作者：
Hadid, R;Spinedi, E;Gaillard, RC
通讯作者：
Gaillard, RC