Endocrine Disruption and Reproductive Pathology.
Endocrine Disruption and Reproductive Pathology.
复制标题
DOI：
10.1177/0192623319879903
复制
发表时间：
2019-12
影响因子：
1.5
通讯作者：
Wolf JC
中科院分区：
文献类型：
--
作者：
Belcher SM;Cline JM;Conley J;Groeters S;Jefferson WN;Law M;Mackey E;Suen AA;Williams CJ;Dixon D;Wolf JC
在过去的20年中，涉及内分泌活性物质（EAS）和生殖毒性的研究主导了生态毒理学研究领域。这与科学界、公众和政府机构对人类和野生动物体内化学物质干扰的潜在后果的认识提高是同步的。我们对内分泌系统的复杂性质及其与外源性物质相互作用的复杂性的认识不断扩展，推动了该领域实验的指数级增长。复杂的因素包括不断增加的新型受体数量和新发现的替代机制途径、环境中化学混合物的影响与单一EAS实验室暴露的影响对比、区分内分泌干扰和直接细胞毒性的挑战以及跨代效应的可能性。尽管最初主要关注EAS对甲状腺和生殖器官的影响，但现在人们认识到，类人物质也可能通过激素机制对神经和免疫系统产生不利影响，并在代谢性疾病（如2型糖尿病和肥胖症）中发挥重要作用。
During the past 20 years, investigations involving endocrine active substances (EAS) and reproductive toxicity have dominated the landscape of ecotoxicological research. This has occurred in concert with heightened awareness in the scientific community, general public, and governmental entities of the potential consequences of chemical perturbation in humans and wildlife. The exponential growth of experimentation in this field is fueled by our expanding knowledge into the complex nature of endocrine systems and the intricacy of their interactions with xenobiotic agents. Complicating factors include the ever-increasing number of novel receptors and alternate mechanistic pathways that have come to light, effects of chemical mixtures in the environment versus those of single EAS laboratory exposures, the challenge of differentiating endocrine disruption from direct cytotoxicity, and the potential for transgenerational effects. Although initially concerned with EAS effects chiefly in the thyroid glands and reproductive organs, it is now recognized that anthropomorphic substances may also adversely affect the nervous and immune systems via hormonal mechanisms and play substantial roles in metabolic diseases, such as type 2 diabetes and obesity.
登录
查看更多内容
影响因子：
3.8
作者：
Beverly, Brandiese E. J.;Lambright, Christy S.;Gray, L. Earl, Jr.
通讯作者：
Gray, L. Earl, Jr.
影响因子：
10.4
作者：
Birnbaum LS;Bucher JR;Collman GW;Zeldin DC;Johnson AF;Schug TT;Heindel JJ
通讯作者：
Heindel JJ
影响因子：
3.6
作者：
BASSETT, JR;CAIRNCROSS, KD
通讯作者：
CAIRNCROSS, KD
DOI：
10.1038/jes.2008.44
发表时间：
2009-02
影响因子：
4.5
作者：
Cao, Yang;Calafat, Antonia M.;Doerge, Daniel R.;Umbach, David M.;Bernbaum, Judy C.;Twaddle, Nathan C.;Ye, Xiaoyun;Rogan, Walter J.
通讯作者：
Rogan, Walter J.
影响因子：
2.9
作者：
Baker, Stephanie;Rees, Stephanie;Bielajew, Catherine
通讯作者：
Bielajew, Catherine