A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls.
A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls.
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DOI：
10.3390/healthcare10020230
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发表时间：
2022-01-26
期刊：
影响因子：
--
通讯作者：
Müller NG
中科院分区：
文献类型：
--
作者：
Herold F;Labott BK;Grässler B;Halfpaap N;Langhans C;Müller P;Ammar A;Dordevic M;Hökelmann A;Müller NG
患有遗忘型轻度认知障碍（aMCI）的老年人除了记忆缺陷外，还患有额叶执行功能障碍，与患有无执行功能障碍的aMCI的老年人和患有非遗忘型MCI（naMCI）的老年人相比，他们在晚年患痴呆症的风险更高。握力（HGS）也与老年人认知能力下降的风险相关。因此，本研究旨在研究HGS与aMCI、naMCI和健康对照个体执行功能之间的相关性。患有遗忘型MCI（aMCI）、非遗忘型MCI（naMCI）和健康对照（HC）的右利手老年人通过手持式测力计进行了握力测量。执行功能采用连线测验（TMT A&B）进行评估。计算标准化的握力（nHGS，标准化为体重指数（BMI）），并通过偏相关分析（即，考虑到年龄、性别和抑郁症状的严重程度）。在aMCI老年人中，观察到右侧nHGS（rp（22）= 0.364; p = 0.063）和左侧nHGS（rp（22）= 0.420; p = 0.037）与执行功能之间存在正相关和低至中度相关性，但在naMCI或HC中未观察到。我们的研究结果表明，较高水平的nHGS与aMCI的执行功能更好有关，但与naMCI和HC无关。这种关系可能是由aMCI老年人中发生的前额叶-前额叶网络完整性的改变所驱动的。需要进一步的研究来为这一假设提供经验证据。
Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
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DOI：
10.1016/j.dadm.2016.03.004
发表时间：
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