Amphetamine sensitization in reproductively experienced female rats.
Amphetamine sensitization in reproductively experienced female rats.
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DOI：
10.1016/j.neulet.2011.07.035
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发表时间：
2011-09-20
影响因子：
2.5
通讯作者：
Byrnes EM
中科院分区：
文献类型：
--
作者：
Byrnes JJ;Bridges RS;Byrnes EM
最近的研究支持了这一假设，即怀孕和分娩与大脑多巴胺系统的敏感性改变有关。哺乳后几周，也观察到对直接作用的D1/D2受体激动剂（阿扑吗啡）的行为敏感性增加，这表明这些适应是持久的。为了进一步描述这一现象，生殖经验对雌性大鼠对间接作用多巴胺受体激动剂（安非他明）的行为敏感化的影响进行了研究。在两个单独的实验中，用安非他明（1.0或5.0 mg/kg）或溶剂（生理盐水）对未经产和经产（断奶后12-16周）雌性大鼠进行预处理，每天一次，连续5天。停药10天后，用低剂量安非他明（治疗前剂量的25%）激发所有动物。在每种药物或溶媒给药后测量自发活动。无论生殖经验如何，在1 mg/kg预处理的所有动物中均观察到对苯丙胺激发的运动致敏作用。相比之下，与未经产的对照相比，用5 mg/kg安非他明预处理的经产动物显示出对挑战的显著更大的运动反应。研究结果表明，增强的行为敏感性安非他明在生殖经验丰富的大鼠，并证实了以前的报告，持久的适应多巴胺系统后，怀孕和哺乳期。
Recent studies have supported the hypothesis that pregnancy and parturition are associated with altered sensitivity of brain dopamine systems. An increased behavioral sensitivity to a direct-acting D1/D2 receptor agonist (apomorphine) has also been observed several weeks after lactation, suggesting that these adaptations are long-lasting. To further characterize this phenomenon, the effects of reproductive experience on behavioral sensitization to an indirect-acting dopamine agonist (amphetamine) in female rats were studied. In two separate experiments, nulliparous and primiparous (12–16 weeks post-weaning) female rats were pretreated with amphetamine (1.0 or 5.0 mg/kg) or vehicle (saline) once daily for 5 consecutive days. After 10 days of withdrawal, all animals were challenged with a low dose of amphetamine (25% of pretreatment dose). Locomotor activity was measured following each drug or vehicle administration. Locomotor sensitization to amphetamine challenge was observed in all animals pretreated with 1 mg/kg, regardless of reproductive experience. In contrast, primiparous animals pretreated with 5 mg/kg amphetamine displayed a significantly larger locomotor response to the challenge compared to nulliparous controls. The findings indicate enhanced behavioral sensitization to amphetamine in reproductively-experienced rats, and confirm previous reports of lasting adaptations of dopamine systems following pregnancy and lactation.
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影响因子：
5.3
作者：
Ahokas, A;Aito, M;Rimón, R
通讯作者：
Rimón, R
影响因子：
3.2
作者：
Byrnes, E. M.;Bridges, R. S.
通讯作者：
Bridges, R. S.
影响因子：
10.5
作者：
MEAKIN, CJ;BROCKINGTON, IF;JONES, SR
通讯作者：
JONES, SR
影响因子：
2.7
作者：
Byrnes, John J.;Gleason, Erin D.;Schoen, Mathew T.;Lovelock, Dennis F.;Carini, Lindsay M.;Byrnes, Elizabeth M.;Bridges, Robert S.
通讯作者：
Bridges, Robert S.
影响因子：
3.4
作者：
Ahokas, A;Aito, M
通讯作者：
Aito, M