Accelerated maternal responding following intra-VTA pertussis toxin treatment.
Accelerated maternal responding following intra-VTA pertussis toxin treatment.
复制标题
百日咳毒素治疗后，加速母体反应。
DOI：
10.1016/j.bbr.2011.04.048
复制
发表时间：
2011-10-01
影响因子：
2.7
通讯作者：
Bridges, Robert S.
中科院分区：
文献类型：
--
作者：
Byrnes, John J.;Gleason, Erin D.;Schoen, Mathew T.;Lovelock, Dennis F.;Carini, Lindsay M.;Byrnes, Elizabeth M.;Bridges, Robert S.
关键词：
先前的研究支持中脑边缘多巴胺能机制在调节母性行为中的作用。因此，腹侧被盖区（VTA）及其多巴胺能投射到丘脑核（NAc）和内侧前额叶皮层（mPFC）已被牵连在正常母性行为的发生和维持。到目前为止，研究的直接操纵腹侧被盖区神经化学在母性行为的发病一直有限。目前的研究进行直接测试的假设，增强中脑边缘多巴胺系统中的多巴胺能传递可以刺激母体活动，使用小狗诱导的处女模型。将百日咳毒素（PTX 0、0.1或0.3 μg/半球）立体定向注入未产雌性大鼠腹侧被盖区，以慢性刺激多巴胺能投射神经元的活动。恢复3天后，每天测试母体对供体幼仔的反应，并记录完全母体行为的潜伏期（以天计）。VTA内PTX治疗产生了强烈的剂量依赖性降低母体行为潜伏期，并长期持续增加自发活动。这些作用与NAc中多巴胺D1受体mRNA表达显著降低有关。未观察到PTX治疗对中脑边缘多巴胺利用或mPFC受体表达的影响。研究结果表明，腹侧被盖区的慢性神经激活通过修饰NAc多巴胺D1受体加速了处女雌性大鼠母性行为的发生。
Prior studies have supported a role for mesolimbic dopaminergic mechanisms in the regulation of maternal behavior. Accordingly, the ventral tegmental area (VTA) and its dopaminergic projections to the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) have been implicated in both the onset and maintenance of normal maternal behavior. To date, studies of direct manipulation of VTA neurochemistry at the onset of maternal behavior have been limited. The current study was undertaken to directly test the hypothesis that enhancement of dopaminergic transmission in the mesolimbic dopamine system can stimulate maternal activity using a pup-induced virgin model. Nulliparous female rats were stereotaxically infused with pertussis toxin (PTX 0, 0.1, or 0.3 μg/hemisphere) into the VTA to chronically stimulate the activity of dopaminergic projection neurons. After 3 days of recovery, maternal responding to donor pups was tested daily, and latency (in days) to full maternal behavior was recorded. Intra-VTA PTX treatment produced a robust dose-dependent decrease in maternal behavior latency, and a long-lasting increase in locomotor activity. These effects were associated with significantly decreased dopamine D1 receptor mRNA expression in the NAc. No effects of PTX treatment on mesolimbic dopamine utilization or mPFC receptor expression were observed. The findings indicate that chronic neural activation in the VTA accelerates the onset of maternal behavior in virgin female rats via modification of the NAc dopamine D1 receptor.
登录
查看更多内容
影响因子：
3.6
作者：
HANSEN, S;BERGVALL, AH;NYIREDI, S
通讯作者：
NYIREDI, S
影响因子：
2.9
作者：
Febo, Marcelo;Felix-Ortiz, Ada C.;Johnson, Tehya R.
通讯作者：
Johnson, Tehya R.
影响因子：
1.9
作者：
Afonso, Veronica M.;Sison, Margarette;Fleming, Alison S.
通讯作者：
Fleming, Alison S.
影响因子：
3.6
作者：
Byrnes, EM;Rigero, BA;Bridges, RS
通讯作者：
Bridges, RS
DOI：
10.1037/h0036414
发表时间：
1974-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
FLEMING, AS;ROSENBLATT, JS
通讯作者：
ROSENBLATT, JS