Patterns of Infant Amygdala Connectivity Mediate the Impact of High Caregiver Affect on Reducing Infant Smiling: Discovery and Replication.
Patterns of Infant Amygdala Connectivity Mediate the Impact of High Caregiver Affect on Reducing Infant Smiling: Discovery and Replication.
复制标题
婴儿杏仁核连接模式调节高照顾者情感对减少婴儿微笑的影响：发现和复制。
DOI：
10.1016/j.biopsych.2021.03.026
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发表时间：
2021-09-01
影响因子：
10.6
通讯作者：
Hipwell AE
中科院分区：
文献类型：
--
作者：
Phillips ML;Schmithorst VJ;Banihashemi L;Taylor M;Samolyk A;Northrup JB;English GE;Versace A;Stiffler RS;Aslam HA;Bonar L;Panigrahy A;Hipwell AE
行为学研究表明，分娩后最初几个月的照顾者情绪障碍和情绪不稳定与婴儿低阳性（PE）和高负性情绪（NE）有关，但其神经机制仍未得到充分研究。使用静息状态功能连接（rs-FC）作为早期婴儿大脑功能结构的测量，我们旨在确定杏仁核（一个支持情绪学习和感知的关键区域）和大规模神经网络之间的连接在多大程度上介导了照顾者情绪和焦虑与早期婴儿NE和PE之间的关联。两个3个月大的婴儿样本（第一个样本：n=58；第二个样本：n=31）在自然睡眠期间进行了MRI扫描。在婴儿期，较高的杏仁核和显著性网络之间的rs-FC，以及较低的杏仁核和执行控制网络rs-FC，在较小程度上介导了照顾者产后抑郁和特质焦虑对婴儿微笑减少的影响（p<0.05， FWE）。此外，第一个样本的结果在第二个独立样本中得到了重复，在更大程度上，照顾者抑郁比照顾者焦虑。我们提供了早期客观神经标记的证据，可以帮助识别那些更有可能受到照顾者抑郁、焦虑和PE减少的有害影响的婴儿，而不是那些可能受到保护的婴儿。
Behavioral research indicates that caregiver mood disorders and emotional instability in the early months following childbirth are associated with lower infant positive (PE) and higher negative emotionality (NE), but the neural mechanisms remain understudied. Using resting state functional connectivity (rs-FC) as a measure of the functional architecture of the early infant brain, we aimed to determine the extent to which connectivity between the amygdala, a key region supporting emotional learning and perception, and large-scale neural networks mediated the association between caregiver mood and anxiety and early infant NE and PE. Two samples of infants (first sample: n=58; second sample: n=31) aged 3-months underwent an MRI scan during natural sleep. During infancy, greater rs-FC between the amygdala and the salience network, and, to a lesser extent, lower amygdala-and executive control network rs-FC, mediated the effect of greater caregiver postpartum depression and trait anxiety on reducing infant smiling (p<0.05, FWE). Furthermore, results from the first sample were replicated in the second, independent sample, to a greater extent for caregiver depression than for caregiver anxiety. We provide evidence of early objective neural markers that can help identify those infants who are more likely to be at risk from, versus those who might be protected against, the deleterious effects of caregiver depression and anxiety and reduced PE.
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影响因子：
4
作者：
Blatt-Eisengart, Ilana;Drabick, Deborah A. G.;Monahan, Kathryn C.;Steinberg, Laurence
通讯作者：
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通讯作者：
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作者：
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通讯作者：
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