Visual experience induces 4-8 Hz synchrony between V1 and higher-order visual areas.

Visual experience induces 4-8 Hz synchrony between V1 and higher-order visual areas.
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DOI:
10.1016/j.celrep.2023.113482
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发表时间:
2023-12-26
期刊:
影响因子:
8.8
通讯作者:
--
中科院分区:
生物学1区
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--
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视觉感知体验会在小鼠初级视觉皮层 (V1) 中引起持续的 4-8 Hz 振荡,编码视觉熟悉度。最近的研究表明,高阶视觉区域(HVA)在功能上是专门化的,并分为处理不同视觉特征的信息流。然而,视觉记忆是否被处理并存储在不同的流中尚不清楚。我们在此报告,在最大程度地引起 LM 反应的视觉刺激夹带后,V1 和外侧内侧 (LM),而不是 V1 和前外侧,在 4-8 Hz 中变得更加相位同步。定向信息分析揭示了 V1 和 HVA 之间自上而下的功能连接的变化。 LM 的光遗传学失活会减少 V1 刺激后的振荡峰值并损害视觉辨别行为。我们的结果表明,4-8 Hz 熟悉诱发的振荡特定于不同的视觉特征,并且存在于相应的 HVA 中,它们可用于在记忆相关行为期间与 V1 进行区域间通信。我们证明,视觉熟悉度会诱导小鼠高阶视觉区域 (HVA) 和 V1 之间的 4-8 Hz 同步。定向信息分析揭示了从 HVA 到 V1 的功能连接的变化。在视觉刺激后的延迟期内,LM 的光遗传学失活降低了 V1 的 4-8 Hz 振荡幅度,并损害了视觉辨别行为。
Visual perceptual experience induces persistent 4–8 Hz oscillations in the mouse primary visual cortex (V1), encoding visual familiarity. Recent studies suggest that higher-order visual areas (HVAs) are functionally specialized and segregated into information streams processing distinct visual features. However, whether visual memories are processed and stored within the distinct streams is not understood. We report here that V1 and lateromedial (LM), but not V1 and anterolateral, become more phase synchronized in 4–8 Hz after the entrainment of visual stimulus that maximally induces responses in LM. Directed information analysis reveals changes in the top-down functional connectivity between V1 and HVAs. Optogenetic inactivation of LM reduces post-stimulus oscillation peaks in V1 and impairs visual discrimination behavior. Our results demonstrate that 4–8 Hz familiarity-evoked oscillations are specific for the distinct visual features and are present in the corresponding HVAs, where they may be used for the inter-areal communication with V1 during memory-related behaviors. We demonstrate that visual familiarity induces 4–8 Hz synchrony between higher-order visual areas (HVAs) and V1 in mice. Directed information analysis revealed changes in the functional connectivity from HVAs to V1. Optogenetic inactivation of LM during the delay period after the visual stimulus reduced the 4–8 Hz oscillation amplitude in V1 and impaired visual discrimination behavior.
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