Central nervous system action of calcitonin to alter experimental gastric ulcers in rats.
Central nervous system action of calcitonin to alter experimental gastric ulcers in rats.
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降钙素改变大鼠实验性胃溃疡的中枢神经系统作用。
DOI：
10.1016/0016-5085(88)90622-1
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发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
KauffmanJr,GL
中科院分区：
文献类型：
--
作者：
Taché,Y;Kolve,E;Maeda-Hagiwara,M;KauffmanJr,GL
本文研究了降钙素对禁食24小时大鼠胃溃疡模型及胃功能的中枢影响。脑池内注射鲑鱼降钙素（5 μg）可完全抑制由冷束缚应激、脑池内注射稳定的促甲状腺激素释放激素类似物或口服阿司匹林诱导的胃溃疡。相比之下，脑池内降钙素增强胃病变引起的口服40%乙醇或0.6 N盐酸。降钙素的作用是剂量依赖性的（0.01-1 μg），并且是中枢神经系统介导的，因为静脉内给予的降钙素剂量比脑池内有效剂量高50倍，并没有显著改变阿司匹林或乙醇引起的胃粘膜损伤。脑池内注射降钙素0.01 μg可抑制幽门结扎大鼠胃酸分泌90%，在0.01 ~ 5 μg范围内可抑制胃排空63%~ 94%。脑池内注射降钙素对胃粘膜中前列腺素的生成没有影响。这些结果表明，脑池内降钙素在脑内起作用，有效地防止由应激、促甲状腺激素释放激素类似物或阿司匹林引起的溃疡形成，但对坏死因子没有细胞保护作用。降钙素的作用与胃前列腺素生成的改变无关，但可能涉及胃分泌和运动功能的抑制。
The central nervous system action of calcitonin to influence various experimental models of gastric ulcers and gastric function was studied in rats fasted for 24 h. Intracisternal injection of salmon calcitonin (5 μg) completely suppressed gastric ulcerations induced by exposure to cold restraint stress, intracisternal injection of a stable thyrotropin-releasing hormone analogue, or peroral administration of aspirin. By contrast, intracisternal calcitonin enhanced gastric lesions elicited by peroral administration of 40% ethanol or 0.6 N HCl. Calcitonin action was dose-dependent (0.01–1 μg) and central nervous system mediated inasmuch as intravenous calcitonin, given at a dose 50-fold higher than that effective intracisternally, did not significantly modify gastric mucosal injuries elicited by aspirin or ethanol. Intracisternal injection of calcitonin at 0.01 μg inhibited gastric acid output by 90% in pylorus-ligated rats and suppressed gastric emptying of a liquid meal by 63%–94% in doses ranging from 0.01 to 5 μg. Prostaglandin generation in the gastric mucosa was not modified by intracisternal injection of calcitonin. These results demonstrate that intracisternal calcitonin acts within the brain to potently prevent ulcer formation elicited by stress, thyrotropin-releasing hormone analogue, or aspirin, but is not cytoprotective against necrotizing agents. Calcitonin action is not related to modification of gastric prostaglandin generation but it may involve the inhibition of gastric secretory and motor function.
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